Elevation of pro-inflammatory cytokine levels following intra-articular fractures - a systematic review

Abstract: Introduction: Intra-articular fractures are a major cause of post-traumatic osteoarthritis (PTOA). Despite adequate surgical treatment, the long-term risk for PTOA is high. Previous studies reported that joint injuries initiate an inflammatory cascade characterized by an elevation of synovial pro-inflammatory cytokines, which can lead to cartilage degradation and PTOA development. This review summarizes the literature on the post-injury regulation of pro-inflammatory cytokines and the markers of cartilage destruction in patients suffering from intra-articular fractures. Methods: We searched Medline, Embase, and Cochrane databases (1960–February 2020) and included studies that were performed on human participants, and we included control groups. Two investigators assessed the quality of the included studies using Covidence and the Newcastle–Ottawa Scale. Results: Based on the surveyed literature, several synovial pro-inflammatory cytokines, including interleukins (IL)-1β, IL-2, IL-6, IL-8, IL-12p70, interferon-y, and tumor necrosis factor-α, were significantly elevated in patients suffering from intra-articular fractures compared to the control groups. A simultaneous elevation of anti-inflammatory cytokines such as IL-10 and IL-1RA was also observed. In contrast, IL-13, CTX-II, and aggrecan concentrations did not differ significantly between the compared cohorts. Conclusions: Overall, intra-articular fractures are associated with an increase in inflammation-related synovial cytokines. However, more standardized studies which focus on the ratio of pro- and anti-inflammatory cytokines at different time points are needed

Location
Deutsche Nationalbibliothek Frankfurt am Main
Extent
Online-Ressource
Language
Englisch
Notes
Cells. - 10, 4 (2021) , 902, ISSN: 2073-4409

Event
Veröffentlichung
(where)
Freiburg
(who)
Universität
(when)
2021
Creator
Pham, That Minh
Erichsen, Julie Ladeby
Kowal, Justyna M.
Overgaard, Søren
Schmal, Hagen

DOI
10.3390/cells10040902
URN
urn:nbn:de:bsz:25-freidok-2179922
Rights
Der Zugriff auf das Objekt ist unbeschränkt möglich.
Last update
25.03.2025, 1:46 PM CET

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Associated

  • Pham, That Minh
  • Erichsen, Julie Ladeby
  • Kowal, Justyna M.
  • Overgaard, Søren
  • Schmal, Hagen
  • Universität

Time of origin

  • 2021

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