Early intraarticular complement activation in ankle fractures
Abstract: Cytokine regulation possibly influences long term outcome following ankle fractures, but little is known about synovial fracture biochemistry. Eight patients with an ankle dislocation fracture were included in a prospective case series and matched with patients suffering from grade 2 osteochondritis dissecans (OCD) of the ankle. All fractures needed external fixation during which joint effusions were collected. Fluid analysis was done by ELISA measuring aggrecan, bFGF, IL-1β, IGF-1, and the complement components C3a, C5a, and C5b-9. The time periods between occurrence of fracture and collection of effusion were only significantly associated with synovial aggrecan and C5b-9 levels (). Furthermore, synovial expressions of both proteins correlated with each other (). Although IL-1β expression was relatively low, intra-articular levels correlated with C5a () and serological C-reactive protein concentrations 2 days after surgery (). Joint effusions were initially dominated by neutrophils, but the portion of monocytes constantly increased reaching 50% at day 6 after fracture (). Whereas aggrecan and IL-1β concentrations were not different in fracture and OCD patients, bFGF, IGF-1, and all complement components were significantly higher concentrated in ankle joints with fractures (). Complement activation and inflammatory cell infiltration characterize the joint biology following acute ankle fractures
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Notes
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BioMed research international. 2014 (2014), Article ID 426893, DOI 10.1155/2014/426893, issn: 2314-6133
IN COPYRIGHT http://rightsstatements.org/page/InC/1.0 rs
- Classification
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Medizin, Gesundheit
- Event
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Veröffentlichung
- (where)
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Freiburg
- (who)
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Universität
- (when)
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2014
- DOI
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10.1155/2014/426893
- URN
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urn:nbn:de:bsz:25-freidok-120001
- Rights
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Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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25.03.2025, 1:53 PM CET
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Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
Time of origin
- 2014
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