Inborn errors of immunity associated with defects of self‐tolerance checkpoints: the CD28 family

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Abstract: One of the causes of inborn errors of immunity is immune dysregulation. The inability of the immune system to regulate the extent of its activity has several deleterious effects, including autoimmunity, recurrent infections, and malignancy. In recent years, many proteins in the CD28 family – CD28, ICOS, CTLA-4, PD-1, and BTLA – have come into the focus of several research areas for their consequential role in the upregulation or downregulation of the immune response. In this review, we will discuss the structure and function of these proteins, as well as provide an overview of the clinical picture of patients with genetic defects

Location: Deutsche Nationalbibliothek Frankfurt am Main

Extent: Online-Ressource

Language: Englisch

Notes: Pediatric allergy and immunology. - 33, 12 (2022) , e13886, ISSN: 1399-3038

Event: Veröffentlichung

(where): Freiburg

(who): Universität

(when): 2022

Creator: Rush‐Kittle, Jorrell
Gámez, Laura
Grimbacher, Bodo

DOI: 10.1111/pai.13886

URN: urn:nbn:de:bsz:25-freidok-2323747

Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.

Last update: 25.03.2025, 1:52 PM CET

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Associated

Rush‐Kittle, Jorrell
Gámez, Laura
Grimbacher, Bodo
Universität

Time of origin

2022

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Inborn errors of immunity associated with defects of self‐tolerance checkpoints: the CD28 family

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Other Objects (12)

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