Inborn errors of immunity associated with defects of self‐tolerance checkpoints: the CD28 family

Abstract: One of the causes of inborn errors of immunity is immune dysregulation. The inability of the immune system to regulate the extent of its activity has several deleterious effects, including autoimmunity, recurrent infections, and malignancy. In recent years, many proteins in the CD28 family – CD28, ICOS, CTLA-4, PD-1, and BTLA – have come into the focus of several research areas for their consequential role in the upregulation or downregulation of the immune response. In this review, we will discuss the structure and function of these proteins, as well as provide an overview of the clinical picture of patients with genetic defects

Standort
Deutsche Nationalbibliothek Frankfurt am Main
Umfang
Online-Ressource
Sprache
Englisch
Anmerkungen
Pediatric allergy and immunology. - 33, 12 (2022) , e13886, ISSN: 1399-3038

Ereignis
Veröffentlichung
(wo)
Freiburg
(wer)
Universität
(wann)
2022
Urheber
Rush‐Kittle, Jorrell
Gámez, Laura
Grimbacher, Bodo

DOI
10.1111/pai.13886
URN
urn:nbn:de:bsz:25-freidok-2323747
Rechteinformation
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
Letzte Aktualisierung
25.03.2025, 13:52 MEZ

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  • 2022

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