Preclinical evaluation of the novel [18F]CHDI-650 PET ligand for non-invasive quantification of mutant huntingtin aggregates in Huntington's disease

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Location: Deutsche Nationalbibliothek Frankfurt am Main

Extent: 1 Online-Ressource.

Language: Englisch

Bibliographic citation: Preclinical evaluation of the novel [18F]CHDI-650 PET ligand for non-invasive quantification of mutant huntingtin aggregates in Huntington's disease ; day:27 ; month:8 ; year:2024 ; pages:1-12
European journal of nuclear medicine and molecular imaging ; (27.8.2024), 1-12

Creator: Zajicek, Franziska
Verhaeghe, Jeroen
Lombaerde, Stef De
Eetveldt, Annemie Van
Miranda, Alan
Munoz-Sanjuan, Ignacio
Dominguez, Celia
Khetarpal, Vinod
Bard, Jonathan
Liu, Longbin
Staelens, Steven
Bertoglio, Daniele

Contributor: SpringerLink (Online service)

DOI: 10.1007/s00259-024-06880-x

URN: urn:nbn:de:101:1-2411130729548.306537085060

Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.

Last update: 15.08.2025, 7:24 AM CEST

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Associated

Zajicek, Franziska
Verhaeghe, Jeroen
Lombaerde, Stef De
Eetveldt, Annemie Van
Miranda, Alan
Munoz-Sanjuan, Ignacio
Dominguez, Celia
Khetarpal, Vinod
Bard, Jonathan
Liu, Longbin
Staelens, Steven
Bertoglio, Daniele
SpringerLink (Online service)

Other Objects (12)

Soluble mutant huntingtin drives early human pathogenesis in Huntington’s disease

HAP40 modulates mutant Huntingtin aggregation and toxicity in Huntington’s disease mice

Genistein induces degradation of mutant huntingtin in fibroblasts from Huntington’s disease patients

Analysis of mutant and total huntingtin expression in Huntington’s disease murine models

Mutant huntingtin induces iron overload via up-regulating IRP1 in Huntington’s disease

Longitudinal preclinical evaluation of the novel radioligand [11C]CHDI-626 for PET imaging of mutant huntingtin aggregates in Huntington’s disease

Hochschulschrift

Analysis of mutant huntingtin aggregation and toxicity in Drosophila models of Huntington’s disease

Mutant huntingtin confers cell-autonomous phenotypes on Huntington’s disease iPSC-derived microglia

Inducible mutant huntingtin expression in HN10 cells reproduces Huntington's disease-like neuronal dysfunction

Discovery of an autophagy inducer J3 to lower mutant huntingtin and alleviate Huntington’s disease-related phenotype

Preventing mutant huntingtin proteolysis and intermittent fasting promote autophagy in models of Huntington disease

TBK1 phosphorylates mutant Huntingtin and suppresses its aggregation and toxicity in Huntington's disease models

Soluble mutant huntingtin drives early human pathogenesis in Huntington’s disease

HAP40 modulates mutant Huntingtin aggregation and toxicity in Huntington’s disease mice

Genistein induces degradation of mutant huntingtin in fibroblasts from Huntington’s disease patients

Analysis of mutant and total huntingtin expression in Huntington’s disease murine models

Mutant huntingtin induces iron overload via up-regulating IRP1 in Huntington’s disease

Longitudinal preclinical evaluation of the novel radioligand [11C]CHDI-626 for PET imaging of mutant huntingtin aggregates in Huntington’s disease

Hochschulschrift

Analysis of mutant huntingtin aggregation and toxicity in Drosophila models of Huntington’s disease

Mutant huntingtin confers cell-autonomous phenotypes on Huntington’s disease iPSC-derived microglia

Inducible mutant huntingtin expression in HN10 cells reproduces Huntington's disease-like neuronal dysfunction

Discovery of an autophagy inducer J3 to lower mutant huntingtin and alleviate Huntington’s disease-related phenotype

Preventing mutant huntingtin proteolysis and intermittent fasting promote autophagy in models of Huntington disease

TBK1 phosphorylates mutant Huntingtin and suppresses its aggregation and toxicity in Huntington's disease models

Soluble mutant huntingtin drives early human pathogenesis in Huntington’s disease

HAP40 modulates mutant Huntingtin aggregation and toxicity in Huntington’s disease mice

Genistein induces degradation of mutant huntingtin in fibroblasts from Huntington’s disease patients

Analysis of mutant and total huntingtin expression in Huntington’s disease murine models

Mutant huntingtin induces iron overload via up-regulating IRP1 in Huntington’s disease

Longitudinal preclinical evaluation of the novel radioligand [11C]CHDI-626 for PET imaging of mutant huntingtin aggregates in Huntington’s disease

Hochschulschrift

Analysis of mutant huntingtin aggregation and toxicity in Drosophila models of Huntington’s disease

Mutant huntingtin confers cell-autonomous phenotypes on Huntington’s disease iPSC-derived microglia

Inducible mutant huntingtin expression in HN10 cells reproduces Huntington's disease-like neuronal dysfunction

Discovery of an autophagy inducer J3 to lower mutant huntingtin and alleviate Huntington’s disease-related phenotype

Preventing mutant huntingtin proteolysis and intermittent fasting promote autophagy in models of Huntington disease

TBK1 phosphorylates mutant Huntingtin and suppresses its aggregation and toxicity in Huntington's disease models

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Preclinical evaluation of the novel [18F]CHDI-650 PET ligand for non-invasive quantification of mutant huntingtin aggregates in Huntington's disease

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Other Objects (12)

Soluble mutant huntingtin drives early human pathogenesis in Huntington’s disease

HAP40 modulates mutant Huntingtin aggregation and toxicity in Huntington’s disease mice

Genistein induces degradation of mutant huntingtin in fibroblasts from Huntington’s disease patients

Analysis of mutant and total huntingtin expression in Huntington’s disease murine models

Mutant huntingtin induces iron overload via up-regulating IRP1 in Huntington’s disease

Longitudinal preclinical evaluation of the novel radioligand [11C]CHDI-626 for PET imaging of mutant huntingtin aggregates in Huntington’s disease

Analysis of mutant huntingtin aggregation and toxicity in Drosophila models of Huntington’s disease

Mutant huntingtin confers cell-autonomous phenotypes on Huntington’s disease iPSC-derived microglia

Inducible mutant huntingtin expression in HN10 cells reproduces Huntington's disease-like neuronal dysfunction

Discovery of an autophagy inducer J3 to lower mutant huntingtin and alleviate Huntington’s disease-related phenotype

Preventing mutant huntingtin proteolysis and intermittent fasting promote autophagy in models of Huntington disease

TBK1 phosphorylates mutant Huntingtin and suppresses its aggregation and toxicity in Huntington's disease models

Soluble mutant huntingtin drives early human pathogenesis in Huntington’s disease

HAP40 modulates mutant Huntingtin aggregation and toxicity in Huntington’s disease mice

Genistein induces degradation of mutant huntingtin in fibroblasts from Huntington’s disease patients

Analysis of mutant and total huntingtin expression in Huntington’s disease murine models

Mutant huntingtin induces iron overload via up-regulating IRP1 in Huntington’s disease

Longitudinal preclinical evaluation of the novel radioligand [11C]CHDI-626 for PET imaging of mutant huntingtin aggregates in Huntington’s disease

Analysis of mutant huntingtin aggregation and toxicity in Drosophila models of Huntington’s disease

Mutant huntingtin confers cell-autonomous phenotypes on Huntington’s disease iPSC-derived microglia

Inducible mutant huntingtin expression in HN10 cells reproduces Huntington's disease-like neuronal dysfunction

Discovery of an autophagy inducer J3 to lower mutant huntingtin and alleviate Huntington’s disease-related phenotype

Preventing mutant huntingtin proteolysis and intermittent fasting promote autophagy in models of Huntington disease

TBK1 phosphorylates mutant Huntingtin and suppresses its aggregation and toxicity in Huntington's disease models

Soluble mutant huntingtin drives early human pathogenesis in Huntington’s disease

HAP40 modulates mutant Huntingtin aggregation and toxicity in Huntington’s disease mice

Genistein induces degradation of mutant huntingtin in fibroblasts from Huntington’s disease patients

Analysis of mutant and total huntingtin expression in Huntington’s disease murine models

Mutant huntingtin induces iron overload via up-regulating IRP1 in Huntington’s disease

Longitudinal preclinical evaluation of the novel radioligand [11C]CHDI-626 for PET imaging of mutant huntingtin aggregates in Huntington’s disease

Analysis of mutant huntingtin aggregation and toxicity in Drosophila models of Huntington’s disease

Mutant huntingtin confers cell-autonomous phenotypes on Huntington’s disease iPSC-derived microglia

Inducible mutant huntingtin expression in HN10 cells reproduces Huntington's disease-like neuronal dysfunction

Discovery of an autophagy inducer J3 to lower mutant huntingtin and alleviate Huntington’s disease-related phenotype

Preventing mutant huntingtin proteolysis and intermittent fasting promote autophagy in models of Huntington disease

TBK1 phosphorylates mutant Huntingtin and suppresses its aggregation and toxicity in Huntington's disease models

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