TBK1 phosphorylates mutant Huntingtin and suppresses its aggregation and toxicity in Huntington's disease models
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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TBK1 phosphorylates mutant Huntingtin and suppresses its aggregation and toxicity in Huntington's disease models ; volume:39 ; number:17 ; year:2020 ; extent:25
The EMBO journal / European Molecular Biology Organization ; 39, Heft 17 (2020) (gesamt 25)
- Urheber
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Hegde, Ramanath Narayana
Chiki, Anass
Petricca, Lara
Martufi, Paola
Arbez, Nicolas
Mouchiroud, Laurent
Auwerx, Johan
Landles, Christian
Bates, Gillian P.
Singh‐Bains, Malvindar K.
Dragunow, Mike
Curtis, Maurice A.
Faull, Richard LM
Ross, Christopher A.
Caricasole, Andrea
Lashuel, Hilal A.
- DOI
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10.15252/embj.2020104671
- URN
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urn:nbn:de:101:1-2022062410273405621988
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
- 15.11.20252025, 07:22 MEZ
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Beteiligte
- Hegde, Ramanath Narayana
- Chiki, Anass
- Petricca, Lara
- Martufi, Paola
- Arbez, Nicolas
- Mouchiroud, Laurent
- Auwerx, Johan
- Landles, Christian
- Bates, Gillian P.
- Singh‐Bains, Malvindar K.
- Dragunow, Mike
- Curtis, Maurice A.
- Faull, Richard LM
- Ross, Christopher A.
- Caricasole, Andrea
- Lashuel, Hilal A.
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Analysis of mutant huntingtin aggregation and toxicity in Drosophila models of Huntington’s disease
Soluble mutant huntingtin drives early human pathogenesis in Huntington’s disease
Genistein induces degradation of mutant huntingtin in fibroblasts from Huntington’s disease patients
Analysis of mutant and total huntingtin expression in Huntington’s disease murine models
Mutant huntingtin induces iron overload via up-regulating IRP1 in Huntington’s disease
Siah-1-interacting protein regulates mutated huntingtin protein aggregation in Huntington’s disease models
Mutant huntingtin confers cell-autonomous phenotypes on Huntington’s disease iPSC-derived microglia
ROCK-phosphorylated vimentin modifies mutant huntingtin aggregation via sequestration of IRBIT
Inducible mutant huntingtin expression in HN10 cells reproduces Huntington's disease-like neuronal dysfunction
Discovery of an autophagy inducer J3 to lower mutant huntingtin and alleviate Huntington’s disease-related phenotype
Preventing mutant huntingtin proteolysis and intermittent fasting promote autophagy in models of Huntington disease
HAP40 modulates mutant Huntingtin aggregation and toxicity in Huntington’s disease mice
Analysis of mutant huntingtin aggregation and toxicity in Drosophila models of Huntington’s disease
Soluble mutant huntingtin drives early human pathogenesis in Huntington’s disease
Genistein induces degradation of mutant huntingtin in fibroblasts from Huntington’s disease patients
Analysis of mutant and total huntingtin expression in Huntington’s disease murine models
Mutant huntingtin induces iron overload via up-regulating IRP1 in Huntington’s disease
Siah-1-interacting protein regulates mutated huntingtin protein aggregation in Huntington’s disease models
Mutant huntingtin confers cell-autonomous phenotypes on Huntington’s disease iPSC-derived microglia
ROCK-phosphorylated vimentin modifies mutant huntingtin aggregation via sequestration of IRBIT
Inducible mutant huntingtin expression in HN10 cells reproduces Huntington's disease-like neuronal dysfunction
Discovery of an autophagy inducer J3 to lower mutant huntingtin and alleviate Huntington’s disease-related phenotype