Hochschulschrift

Analysis of mutant huntingtin aggregation and toxicity in Drosophila models of Huntington’s disease

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Alternative title: Analyse der Aggregation und Toxizität von mutanten Huntingtin in Drosophila Modellen von Chorea Huntington.

Location: Deutsche Nationalbibliothek Frankfurt am Main

Extent: Online-Ressource

Language: Englisch

Notes: Berlin, Freie Universität Berlin, Dissertation, 2017

Keyword: Hirnkrankheit
Neuropsychiatrie
Nervenkrankheit

Event: Veröffentlichung

(where): Berlin

(who): Freie Universität Berlin

(when): 2017

Creator: Schindler, Franziska

URN: urn:nbn:de:kobv:188-fudissthesis000000104246-2

Rights: Der Zugriff auf das Objekt ist unbeschränkt möglich.

Last update: 14.08.2025, 10:56 AM CEST

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Hochschulschrift

Associated

Schindler, Franziska
Freie Universität Berlin

Time of origin

2017

Other Objects (12)

HAP40 modulates mutant Huntingtin aggregation and toxicity in Huntington’s disease mice

TBK1 phosphorylates mutant Huntingtin and suppresses its aggregation and toxicity in Huntington's disease models

Soluble mutant huntingtin drives early human pathogenesis in Huntington’s disease

Nucleolar stress controls mutant Huntington toxicity and monitors Huntington’s disease progression

Genistein induces degradation of mutant huntingtin in fibroblasts from Huntington’s disease patients

Analysis of mutant and total huntingtin expression in Huntington’s disease murine models

Mutant huntingtin induces iron overload via up-regulating IRP1 in Huntington’s disease

Mutant huntingtin confers cell-autonomous phenotypes on Huntington’s disease iPSC-derived microglia

Siah-1-interacting protein regulates mutated huntingtin protein aggregation in Huntington’s disease models

Discovery of an autophagy inducer J3 to lower mutant huntingtin and alleviate Huntington’s disease-related phenotype

Polyglutamine expansion affects huntingtin conformation in multiple Huntington’s disease models

Correlative light and electron microscopy suggests that mutant huntingtin dysregulates the endolysosomal pathway in presymptomatic Huntington’s disease

HAP40 modulates mutant Huntingtin aggregation and toxicity in Huntington’s disease mice

TBK1 phosphorylates mutant Huntingtin and suppresses its aggregation and toxicity in Huntington's disease models

Soluble mutant huntingtin drives early human pathogenesis in Huntington’s disease

Nucleolar stress controls mutant Huntington toxicity and monitors Huntington’s disease progression

Genistein induces degradation of mutant huntingtin in fibroblasts from Huntington’s disease patients

Analysis of mutant and total huntingtin expression in Huntington’s disease murine models

Mutant huntingtin induces iron overload via up-regulating IRP1 in Huntington’s disease

Mutant huntingtin confers cell-autonomous phenotypes on Huntington’s disease iPSC-derived microglia

Siah-1-interacting protein regulates mutated huntingtin protein aggregation in Huntington’s disease models

Discovery of an autophagy inducer J3 to lower mutant huntingtin and alleviate Huntington’s disease-related phenotype

Polyglutamine expansion affects huntingtin conformation in multiple Huntington’s disease models

Correlative light and electron microscopy suggests that mutant huntingtin dysregulates the endolysosomal pathway in presymptomatic Huntington’s disease

HAP40 modulates mutant Huntingtin aggregation and toxicity in Huntington’s disease mice

TBK1 phosphorylates mutant Huntingtin and suppresses its aggregation and toxicity in Huntington's disease models

Soluble mutant huntingtin drives early human pathogenesis in Huntington’s disease

Nucleolar stress controls mutant Huntington toxicity and monitors Huntington’s disease progression

Genistein induces degradation of mutant huntingtin in fibroblasts from Huntington’s disease patients

Analysis of mutant and total huntingtin expression in Huntington’s disease murine models

Mutant huntingtin induces iron overload via up-regulating IRP1 in Huntington’s disease

Mutant huntingtin confers cell-autonomous phenotypes on Huntington’s disease iPSC-derived microglia

Siah-1-interacting protein regulates mutated huntingtin protein aggregation in Huntington’s disease models

Discovery of an autophagy inducer J3 to lower mutant huntingtin and alleviate Huntington’s disease-related phenotype

Polyglutamine expansion affects huntingtin conformation in multiple Huntington’s disease models

Correlative light and electron microscopy suggests that mutant huntingtin dysregulates the endolysosomal pathway in presymptomatic Huntington’s disease

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Analysis of mutant huntingtin aggregation and toxicity in Drosophila models of Huntington’s disease

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Other Objects (12)

HAP40 modulates mutant Huntingtin aggregation and toxicity in Huntington’s disease mice

TBK1 phosphorylates mutant Huntingtin and suppresses its aggregation and toxicity in Huntington's disease models

Soluble mutant huntingtin drives early human pathogenesis in Huntington’s disease

Nucleolar stress controls mutant Huntington toxicity and monitors Huntington’s disease progression

Genistein induces degradation of mutant huntingtin in fibroblasts from Huntington’s disease patients

Analysis of mutant and total huntingtin expression in Huntington’s disease murine models

Mutant huntingtin induces iron overload via up-regulating IRP1 in Huntington’s disease

Mutant huntingtin confers cell-autonomous phenotypes on Huntington’s disease iPSC-derived microglia

Siah-1-interacting protein regulates mutated huntingtin protein aggregation in Huntington’s disease models

Discovery of an autophagy inducer J3 to lower mutant huntingtin and alleviate Huntington’s disease-related phenotype

Polyglutamine expansion affects huntingtin conformation in multiple Huntington’s disease models

Correlative light and electron microscopy suggests that mutant huntingtin dysregulates the endolysosomal pathway in presymptomatic Huntington’s disease

HAP40 modulates mutant Huntingtin aggregation and toxicity in Huntington’s disease mice

TBK1 phosphorylates mutant Huntingtin and suppresses its aggregation and toxicity in Huntington's disease models

Soluble mutant huntingtin drives early human pathogenesis in Huntington’s disease

Nucleolar stress controls mutant Huntington toxicity and monitors Huntington’s disease progression

Genistein induces degradation of mutant huntingtin in fibroblasts from Huntington’s disease patients

Analysis of mutant and total huntingtin expression in Huntington’s disease murine models

Mutant huntingtin induces iron overload via up-regulating IRP1 in Huntington’s disease

Mutant huntingtin confers cell-autonomous phenotypes on Huntington’s disease iPSC-derived microglia

Siah-1-interacting protein regulates mutated huntingtin protein aggregation in Huntington’s disease models

Discovery of an autophagy inducer J3 to lower mutant huntingtin and alleviate Huntington’s disease-related phenotype

Polyglutamine expansion affects huntingtin conformation in multiple Huntington’s disease models

Correlative light and electron microscopy suggests that mutant huntingtin dysregulates the endolysosomal pathway in presymptomatic Huntington’s disease

HAP40 modulates mutant Huntingtin aggregation and toxicity in Huntington’s disease mice

TBK1 phosphorylates mutant Huntingtin and suppresses its aggregation and toxicity in Huntington's disease models

Soluble mutant huntingtin drives early human pathogenesis in Huntington’s disease

Nucleolar stress controls mutant Huntington toxicity and monitors Huntington’s disease progression

Genistein induces degradation of mutant huntingtin in fibroblasts from Huntington’s disease patients

Analysis of mutant and total huntingtin expression in Huntington’s disease murine models

Mutant huntingtin induces iron overload via up-regulating IRP1 in Huntington’s disease

Mutant huntingtin confers cell-autonomous phenotypes on Huntington’s disease iPSC-derived microglia

Siah-1-interacting protein regulates mutated huntingtin protein aggregation in Huntington’s disease models

Discovery of an autophagy inducer J3 to lower mutant huntingtin and alleviate Huntington’s disease-related phenotype

Polyglutamine expansion affects huntingtin conformation in multiple Huntington’s disease models

Correlative light and electron microscopy suggests that mutant huntingtin dysregulates the endolysosomal pathway in presymptomatic Huntington’s disease

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