Apolipoprotein E derived from CD11c+ cells ameliorates atherosclerosis

Abstract: Atherosclerosis is studied in models with dysfunctional lipid homeostasis—predominantly the ApoE−/− mouse. The role of antigen-presenting cells (APCs) for lipid homeostasis is not clear. Using a LacZ reporter mouse, we showed that CD11c+ cells were enriched in aortae of ApoE−/− mice. Systemic long-term depletion of CD11c+ cells in ApoE−/− mice resulted in significantly increased plaque formation associated with reduced serum ApoE levels. In CD11ccre+ApoEfl/fl and Albumincre+ApoEfl/fl mice, we could show that ≈70% of ApoE is liver-derived and ≈25% originates from CD11c+ cells associated with significantly increased atherosclerotic plaque burden in both strains. Exposure to acLDL promoted cholesterol efflux from CD11c+ cells and cell-specific deletion of ApoE resulted in increased inflammation reflected by increased IL-1β serum levels. Our results determined for the first time the level of ApoE originating from CD11c+ cells and demonstrated that CD11c+ cells ameliorate atherosclerosis by the secretion of ApoE

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch
• Notes: iScience. - 25, 1 (2022) , 103677, ISSN: 2589-0042

Contributors, Places and Time

• Event: Veröffentlichung
• (where): Freiburg
• (who): Universität
• (when): 2022
• Creator: Sauter, Manuela ; Sauter, Reinhard Jörg ; Nording, Henry ; Lin, Chaolan ; Olbrich, Marcus ; Autenrieth, Stella E. ; Gleißner, Christian A. ; Thunemann, Martin ; Otero, Nadia ; Lutgens, Esther ; Aherrahrou, Zouhair ; Wolf, Dennis ; Zender, Lars ; Meuth, Sven ; Feil, Robert ; Langer, Harald

Further information

• DOI: 10.1016/j.isci.2021.103677
• URN: urn:nbn:de:bsz:25-freidok-2264835
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 15.08.2025, 7:29 AM CEST