Neuraminidase inhibitor zanamivir ameliorates collagen-induced arthritis
Abstract: Altered sialylation patterns play a role in chronic autoimmune diseases such as rheumatoid arthritis (RA). Recent studies have shown the pro-inflammatory activities of immunoglobulins (Igs) with desialylated sugar moieties. The role of neuraminidases (NEUs), enzymes which are responsible for the cleavage of terminal sialic acids (SA) from sialoglycoconjugates, is not fully understood in RA. We investigated the impact of zanamivir, an inhibitor of the influenza virus neuraminidase, and mammalian NEU2/3 on clinical outcomes in experimental arthritides studies. The severity of arthritis was monitored and IgG titers were measured by ELISA. (2,6)-linked SA was determined on IgG by ELISA and on cell surfaces by flow cytometry. Zanamivir at a dose of 100 mg/kg (zana-100) significantly ameliorated collagen-induced arthritis (CIA), whereas zana-100 was ineffective in serum transfer-induced arthritis. Systemic zana-100 treatment reduced the number of splenic CD138+/TACI+ plasma cells and CD19+ B cells, which was associated with lower IgG levels and an increased sialylation status of IgG compared to controls. Our data reveal the contribution of NEU2/3 in CIA. Zanamivir down-modulated the T and B cell-dependent humoral immune response and induced an anti-inflammatory milieu by inhibiting sialic acid degradation. We suggest that neuraminidases might represent a promising therapeutic target for RA and possibly also for other antibody-mediated autoimmune diseases
- Location
-
Deutsche Nationalbibliothek Frankfurt am Main
- Extent
-
Online-Ressource
- Language
-
Englisch
- Notes
-
International journal of molecular sciences. - 22, 3 (2021) , 1428, ISSN: 1422-0067
- Event
-
Veröffentlichung
- (where)
-
Freiburg
- (who)
-
Universität
- (when)
-
2021
- Creator
-
Sehnert, Bettina
Mietz, Juliane
Rzepka, Rita
Buchholz, Stefanie
Maul-Pavicic, Andrea
Schaffer, Sandra
Nimmerjahn, Falk
Voll, Reinhard
- DOI
-
10.3390/ijms22031428
- URN
-
urn:nbn:de:bsz:25-freidok-1761115
- Rights
-
Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
-
25.03.2025, 1:53 PM CET
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Sehnert, Bettina
- Mietz, Juliane
- Rzepka, Rita
- Buchholz, Stefanie
- Maul-Pavicic, Andrea
- Schaffer, Sandra
- Nimmerjahn, Falk
- Voll, Reinhard
- Universität
Time of origin
- 2021
Other Objects (12)
Die Bedeutung der Immunmodulation für Pathogenese und Therapie entzündlich-rheumatischer Erkrankungen
Pathogenesis of autoimmunity in common variable immunodeficiency
Angiotensin AT2 Receptor Stimulation Alleviates Collagen-Induced Arthritis by Upregulation of Regulatory T Cell Numbers
Angiotensin AT2 receptor stimulation alleviates collagen-induced arthritis by upregulation of regulatory T cell numbers
Factors associated with severe COVID-19 in people with idiopathic inflammatory myopathy: results from the COVID-19 Global Rheumatology Alliance physician-reported registry
Increased binding of anti-dsDNA antibodies to short oligonucleotides modified with topoisomerase I reveals a potential new enzyme function independent from DNA relaxation
Editorial: The role of nuclear molecules in the pathogenesis of autoimmune disease
Immunpathogenese des systemischen Lupus erythematodes : = Immunopathogenesis of systemic lupus erythematosus
Immunpathogenese des systemischen Lupus erythematodes : Immunopathogenesis of systemic lupus erythematosus
Analyse der Antikörper-Glykosylierung bei Patienten mit rheumatoider Arthritis
Inflammatory arthritis in systemic sclerosis is associated with elevated C-reactive protein and requires musculoskeletal ultrasound for reliable detection
Cell-type targeted NF-kappaB inhibition for the treatment of inflammatory diseases
Die Bedeutung der Immunmodulation für Pathogenese und Therapie entzündlich-rheumatischer Erkrankungen
Pathogenesis of autoimmunity in common variable immunodeficiency
Angiotensin AT2 Receptor Stimulation Alleviates Collagen-Induced Arthritis by Upregulation of Regulatory T Cell Numbers
Angiotensin AT2 receptor stimulation alleviates collagen-induced arthritis by upregulation of regulatory T cell numbers
Factors associated with severe COVID-19 in people with idiopathic inflammatory myopathy: results from the COVID-19 Global Rheumatology Alliance physician-reported registry
Increased binding of anti-dsDNA antibodies to short oligonucleotides modified with topoisomerase I reveals a potential new enzyme function independent from DNA relaxation
Editorial: The role of nuclear molecules in the pathogenesis of autoimmune disease
Immunpathogenese des systemischen Lupus erythematodes : = Immunopathogenesis of systemic lupus erythematosus
Immunpathogenese des systemischen Lupus erythematodes : Immunopathogenesis of systemic lupus erythematosus
Analyse der Antikörper-Glykosylierung bei Patienten mit rheumatoider Arthritis
Inflammatory arthritis in systemic sclerosis is associated with elevated C-reactive protein and requires musculoskeletal ultrasound for reliable detection
Cell-type targeted NF-kappaB inhibition for the treatment of inflammatory diseases
Die Bedeutung der Immunmodulation für Pathogenese und Therapie entzündlich-rheumatischer Erkrankungen
Pathogenesis of autoimmunity in common variable immunodeficiency
Angiotensin AT2 Receptor Stimulation Alleviates Collagen-Induced Arthritis by Upregulation of Regulatory T Cell Numbers
Angiotensin AT2 receptor stimulation alleviates collagen-induced arthritis by upregulation of regulatory T cell numbers
Factors associated with severe COVID-19 in people with idiopathic inflammatory myopathy: results from the COVID-19 Global Rheumatology Alliance physician-reported registry
Increased binding of anti-dsDNA antibodies to short oligonucleotides modified with topoisomerase I reveals a potential new enzyme function independent from DNA relaxation
Editorial: The role of nuclear molecules in the pathogenesis of autoimmune disease
Immunpathogenese des systemischen Lupus erythematodes : = Immunopathogenesis of systemic lupus erythematosus
Immunpathogenese des systemischen Lupus erythematodes : Immunopathogenesis of systemic lupus erythematosus
Analyse der Antikörper-Glykosylierung bei Patienten mit rheumatoider Arthritis
Inflammatory arthritis in systemic sclerosis is associated with elevated C-reactive protein and requires musculoskeletal ultrasound for reliable detection