Angiotensin AT2 receptor stimulation alleviates collagen-induced arthritis by upregulation of regulatory T cell numbers

to connected objects

Abstract: The angiotensin AT2 receptor (AT2R) is a main receptor of the protective arm of the renin-angiotensin system and exerts for instance anti-inflammatory effects. The impact of AT2R stimulation on autoimmune diseases such as rheumatoid arthritis (RA) is not yet known. We investigated the therapeutic potential of AT2R-stimulation with the selective non-peptide AT2R agonist Compound 21 (C21) in collagen-induced arthritis (CIA), an animal model for inflammatory arthritis. Arthritis was induced by immunization of DBA/1J mice with collagen type II (CII). Prophylactic and therapeutic C21 treatment alleviates arthritis severity and incidence in CIA. Joint histology revealed significantly less infiltrates of IL-1 beta and IL-17A expressing cells and a well-preserved articular cartilage in C21- treated mice. In CIA, the number of CD4+CD25+FoxP3+ regulatory T (Treg) cells significantly increased upon C21 treatment compared to vehicle. T cell differentiation experiments demonstrated increased expression of FoxP3 mRNA, whereas IL-17A, STAT3 and IFN-gamma mRNA expression were reduced upon C21 treatment. In accordance with the mRNA data, C21 upregulated the percentage of CD4+FoxP3+ cells in Treg polarizing cultures compared to medium-treated controls, whereas the percentage of CD4+IL-17A+ and CD4+IFN-gamma+ T cells was suppressed. To conclude, C21 exerts beneficial effects on T cell-mediated experimental arthritis. We found that C21-induced AT2R-stimulation promotes the expansion of CD4+ regulatory T cells and suppresses IL-17A production. Thus, AT2R-stimulation may represent an attractive treatment strategy for arthritis

Location: Deutsche Nationalbibliothek Frankfurt am Main

Extent: Online-Ressource

Language: Englisch

Notes: Frontiers in immunology. - 13 (2022) , 921488, ISSN: 1664-3224

Event: Veröffentlichung

(where): Freiburg

(who): Universität

(when): 2022

Creator: Sehnert, Bettina
Valero Esquitino, Verónica
Schett, Georg
Unger, Thomas
Steckelings, Ulrike
Voll, Reinhard

DOI: 10.3389/fimmu.2022.921488

URN: urn:nbn:de:bsz:25-freidok-2288430

Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.

Last update: 25.03.2025, 1:45 PM CET

Data provider

This object is provided by:
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.

Show original at data provider

Associated

Time of origin

2022

Other Objects (12)

Angiotensin AT2 Receptor Stimulation Alleviates Collagen-Induced Arthritis by Upregulation of Regulatory T Cell Numbers

Angiotensin AT2 Receptor Stimulation Alleviates Collagen-Induced Arthritis by Upregulation of Regulatory T Cell Numbers

Die Bedeutung der Immunmodulation für Pathogenese und Therapie entzündlich-rheumatischer Erkrankungen

Hochschulschrift

Die Bedeutung der Immunmodulation für Pathogenese und Therapie entzündlich-rheumatischer Erkrankungen

Pathogenesis of autoimmunity in common variable immunodeficiency

Pathogenesis of autoimmunity in common variable immunodeficiency

Factors associated with severe COVID-19 in people with idiopathic inflammatory myopathy: results from the COVID-19 Global Rheumatology Alliance physician-reported registry

Factors associated with severe COVID-19 in people with idiopathic inflammatory myopathy: results from the COVID-19 Global Rheumatology Alliance physician-reported registry

Increased binding of anti-dsDNA antibodies to short oligonucleotides modified with topoisomerase I reveals a potential new enzyme function independent from DNA relaxation

Increased binding of anti-dsDNA antibodies to short oligonucleotides modified with topoisomerase I reveals a potential new enzyme function independent from DNA relaxation

Editorial: The role of nuclear molecules in the pathogenesis of autoimmune disease

Editorial: The role of nuclear molecules in the pathogenesis of autoimmune disease

Immunpathogenese des systemischen Lupus erythematodes : = Immunopathogenesis of systemic lupus erythematosus

Immunpathogenese des systemischen Lupus erythematodes : = Immunopathogenesis of systemic lupus erythematosus

Immunpathogenese des systemischen Lupus erythematodes : Immunopathogenesis of systemic lupus erythematosus

Immunpathogenese des systemischen Lupus erythematodes : Immunopathogenesis of systemic lupus erythematosus

Circulating mitochondrial DNA copy numbers represent a sensitive marker for diagnosis and monitoring of disease activity in systemic lupus erythematosus

Circulating mitochondrial DNA copy numbers represent a sensitive marker for diagnosis and monitoring of disease activity in systemic lupus erythematosus

Neuraminidase inhibitor zanamivir ameliorates collagen-induced arthritis

Neuraminidase inhibitor zanamivir ameliorates collagen-induced arthritis

Cell-type targeted NF-kappaB inhibition for the treatment of inflammatory diseases

Cell-type targeted NF-kappaB inhibition for the treatment of inflammatory diseases

Speicheldrüsenultraschall oder Biopsie? : : Methoden im Vergleich anhand von Fallbeispielen = Salivary gland ultrasound or biopsy? : Comparison of methods based on case examples

Speicheldrüsenultraschall oder Biopsie? : : Methoden im Vergleich anhand von Fallbeispielen = Salivary gland ultrasound or biopsy? : Comparison of methods based on case examples

Angiotensin AT2 Receptor Stimulation Alleviates Collagen-Induced Arthritis by Upregulation of Regulatory T Cell Numbers

Angiotensin AT2 Receptor Stimulation Alleviates Collagen-Induced Arthritis by Upregulation of Regulatory T Cell Numbers

Die Bedeutung der Immunmodulation für Pathogenese und Therapie entzündlich-rheumatischer Erkrankungen

Hochschulschrift

Die Bedeutung der Immunmodulation für Pathogenese und Therapie entzündlich-rheumatischer Erkrankungen

Pathogenesis of autoimmunity in common variable immunodeficiency

Pathogenesis of autoimmunity in common variable immunodeficiency

Factors associated with severe COVID-19 in people with idiopathic inflammatory myopathy: results from the COVID-19 Global Rheumatology Alliance physician-reported registry

Factors associated with severe COVID-19 in people with idiopathic inflammatory myopathy: results from the COVID-19 Global Rheumatology Alliance physician-reported registry

Increased binding of anti-dsDNA antibodies to short oligonucleotides modified with topoisomerase I reveals a potential new enzyme function independent from DNA relaxation

Increased binding of anti-dsDNA antibodies to short oligonucleotides modified with topoisomerase I reveals a potential new enzyme function independent from DNA relaxation

Editorial: The role of nuclear molecules in the pathogenesis of autoimmune disease

Editorial: The role of nuclear molecules in the pathogenesis of autoimmune disease

Immunpathogenese des systemischen Lupus erythematodes : = Immunopathogenesis of systemic lupus erythematosus

Immunpathogenese des systemischen Lupus erythematodes : = Immunopathogenesis of systemic lupus erythematosus

Immunpathogenese des systemischen Lupus erythematodes : Immunopathogenesis of systemic lupus erythematosus

Immunpathogenese des systemischen Lupus erythematodes : Immunopathogenesis of systemic lupus erythematosus

Circulating mitochondrial DNA copy numbers represent a sensitive marker for diagnosis and monitoring of disease activity in systemic lupus erythematosus

Circulating mitochondrial DNA copy numbers represent a sensitive marker for diagnosis and monitoring of disease activity in systemic lupus erythematosus

Neuraminidase inhibitor zanamivir ameliorates collagen-induced arthritis

Neuraminidase inhibitor zanamivir ameliorates collagen-induced arthritis

Cell-type targeted NF-kappaB inhibition for the treatment of inflammatory diseases

Cell-type targeted NF-kappaB inhibition for the treatment of inflammatory diseases

Speicheldrüsenultraschall oder Biopsie? : : Methoden im Vergleich anhand von Fallbeispielen = Salivary gland ultrasound or biopsy? : Comparison of methods based on case examples

Speicheldrüsenultraschall oder Biopsie? : : Methoden im Vergleich anhand von Fallbeispielen = Salivary gland ultrasound or biopsy? : Comparison of methods based on case examples

Angiotensin AT2 Receptor Stimulation Alleviates Collagen-Induced Arthritis by Upregulation of Regulatory T Cell Numbers

Angiotensin AT2 Receptor Stimulation Alleviates Collagen-Induced Arthritis by Upregulation of Regulatory T Cell Numbers

Die Bedeutung der Immunmodulation für Pathogenese und Therapie entzündlich-rheumatischer Erkrankungen

Hochschulschrift

Die Bedeutung der Immunmodulation für Pathogenese und Therapie entzündlich-rheumatischer Erkrankungen

Pathogenesis of autoimmunity in common variable immunodeficiency

Pathogenesis of autoimmunity in common variable immunodeficiency

Factors associated with severe COVID-19 in people with idiopathic inflammatory myopathy: results from the COVID-19 Global Rheumatology Alliance physician-reported registry

Factors associated with severe COVID-19 in people with idiopathic inflammatory myopathy: results from the COVID-19 Global Rheumatology Alliance physician-reported registry

Increased binding of anti-dsDNA antibodies to short oligonucleotides modified with topoisomerase I reveals a potential new enzyme function independent from DNA relaxation

Increased binding of anti-dsDNA antibodies to short oligonucleotides modified with topoisomerase I reveals a potential new enzyme function independent from DNA relaxation

Editorial: The role of nuclear molecules in the pathogenesis of autoimmune disease

Editorial: The role of nuclear molecules in the pathogenesis of autoimmune disease

Immunpathogenese des systemischen Lupus erythematodes : = Immunopathogenesis of systemic lupus erythematosus

Immunpathogenese des systemischen Lupus erythematodes : = Immunopathogenesis of systemic lupus erythematosus

Immunpathogenese des systemischen Lupus erythematodes : Immunopathogenesis of systemic lupus erythematosus

Immunpathogenese des systemischen Lupus erythematodes : Immunopathogenesis of systemic lupus erythematosus

Circulating mitochondrial DNA copy numbers represent a sensitive marker for diagnosis and monitoring of disease activity in systemic lupus erythematosus

Circulating mitochondrial DNA copy numbers represent a sensitive marker for diagnosis and monitoring of disease activity in systemic lupus erythematosus

Neuraminidase inhibitor zanamivir ameliorates collagen-induced arthritis

Neuraminidase inhibitor zanamivir ameliorates collagen-induced arthritis

Cell-type targeted NF-kappaB inhibition for the treatment of inflammatory diseases

Cell-type targeted NF-kappaB inhibition for the treatment of inflammatory diseases

Speicheldrüsenultraschall oder Biopsie? : : Methoden im Vergleich anhand von Fallbeispielen = Salivary gland ultrasound or biopsy? : Comparison of methods based on case examples

Speicheldrüsenultraschall oder Biopsie? : : Methoden im Vergleich anhand von Fallbeispielen = Salivary gland ultrasound or biopsy? : Comparison of methods based on case examples

Cultural heritage institutions wishing to register will find more information here.

Fields marked * need to be filled in.

Username*

Please enter your username

Email*

Please enter your email address

Please do not fill this field

First name

Last name

Password*

Please enter your password

Confirm password*

Please enter the same password

I have read the terms of use and the privacy policy for the collection of personal data and accept them. *

This field is required.

I would like to subscribe to the newsletter of the Deutsche Digitale Bibliothek. See newsletter subscription info.

Account created

Your "My DDB" account has been successfully created. Before you can log in to your account, you must click the confirmation link in the message we just sent to the email address you provided.