Establishing connectivity through microdissections of midbrain stimulation-related neural circuits
Abstract: Comprehensive understanding of the neural circuits involving the ventral tegmental area is essential for elucidating the anatomofunctional mechanisms governing human behaviour, in addition to the therapeutic and adverse effects of deep brain stimulation for neuropsychiatric diseases. Although the ventral tegmental area has been targeted successfully with deep brain stimulation for different neuropsychiatric diseases, the axonal connectivity of the region is not fully understood.
Here, using fibre microdissections in human cadaveric hemispheres, population-based high-definition fibre tractography and previously reported deep brain stimulation hotspots, we find that the ventral tegmental area participates in an intricate network involving the serotonergic pontine nuclei, basal ganglia, limbic system, basal forebrain and prefrontal cortex, which is implicated in the treatment of obsessive–compulsive disorder, major depressive disorder, Alzheimer’s disease, cluster headaches and aggressive behaviours
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Anmerkungen
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Brain. - 147, 9 (2024) , 3083-3098, ISSN: 1460-2156
- Ereignis
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Veröffentlichung
- (wo)
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Freiburg
- (wer)
-
Universität
- (wann)
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2024
- Urheber
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Skandalakis, Georgios P.
Neudorfer, Clemens
Payne, Caitlin A.
Bond, Evalina
Tavakkoli, Armin D.
Barrios-Martinez, Jessica
Trutti, Anne C.
Koutsarnakis, Christos
Coenen, Volker Arnd
Komaitis, Spyridon
Hadjipanayis, Constantinos G.
Stranjalis, George
Yeh, Fang-Cheng
Banihashemi, Layla
Hong, Jennifer
Lozano, Andres M.
Kogan, Michael
Horn, Andreas
Evans, Linton T.
Kalyvas, Aristotelis
- DOI
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10.1093/brain/awae173
- URN
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urn:nbn:de:bsz:25-freidok-2492737
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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15.08.2025, 07:30 MESZ
Datenpartner
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Beteiligte
- Skandalakis, Georgios P.
- Neudorfer, Clemens
- Payne, Caitlin A.
- Bond, Evalina
- Tavakkoli, Armin D.
- Barrios-Martinez, Jessica
- Trutti, Anne C.
- Koutsarnakis, Christos
- Coenen, Volker Arnd
- Komaitis, Spyridon
- Hadjipanayis, Constantinos G.
- Stranjalis, George
- Yeh, Fang-Cheng
- Banihashemi, Layla
- Hong, Jennifer
- Lozano, Andres M.
- Kogan, Michael
- Horn, Andreas
- Evans, Linton T.
- Kalyvas, Aristotelis
- Universität
Entstanden
- 2024
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