Retinal vessel volume reference database derived from volume-rendered optical coherence tomography angiography

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Abstract: Optical coherence tomography angiography (OCTA) enables three-dimensional reconstruction of the functional blood vessels in the retina. Therefore, it enables the quantification of 3D retinal vessel parameters such as surface area and vessel volume. In spite of the widespread use of OCTA, no representative volume-rendered vessel volume (VV) data are published to date. In this study, OCTA 3 × 3 mm macular cubes were processed with volume-rendering techniques to measure VV in 203 eyes from 107 healthy volunteers. Generalized linear models (GLM) were constructed to assess the impact of age, gender, visual acuity (VA), spherical equivalent (SE), and axial length (AL) on VV. Overall mean VV was 0.23 ± 0.05mm3. Age and axial length showed a negative correlation with VV. However, GLM model analysis found that AL exerted the most pronounced influence on VV. No statistically significant associations were identified between gender or between left and right eyes. This is the first study to assess 3D OCTA VV and its naturally occurring variations in a large series of healthy subjects. It offers novel insights into the characterization of normal retinal vascular anatomy in healthy individuals, contributing to a valuable reference for future research in this field

Standort
Deutsche Nationalbibliothek Frankfurt am Main
Umfang
Online-Ressource
Sprache
Englisch
Anmerkungen
Scientific reports. - 14, 1 (2024) , 2721, ISSN: 2045-2322

Ereignis
Veröffentlichung
(wo)
Freiburg
(wer)
Universität
(wann)
2024
Urheber
Feu-Basilio, Silvia
Maloca, Peter M.
Hasler, Pascal W.
Scholl, Hendrik Peter Nicolas
Marin-Martinez, Sara
Rosinés-Fonoll, Josep
Suarez-Valero, Xavier
Reich, Michael
Lange, Clemens
Egan, Catherine
Zweifel, Sandrine A.
Tufail, Adnan
Spaide, Richard F.
Zarranz-Ventura, Javier

DOI
10.1038/s41598-024-53000-8
URN
urn:nbn:de:bsz:25-freidok-2440299
Rechteinformation
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
Letzte Aktualisierung
25.03.2025, 13:46 MEZ

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