Reference database of total retinal vessel surface area derived from volume-rendered optical coherence tomography angiography

Abstract: Optical coherence tomography angiography (OCTA) enables three-dimensional, high-resolution, depth-resolved flow to be distinguished from non-vessel tissue signals in the retina. Thus, it enables the quantification of the 3D surface area of the retinal vessel signal. Despite the widespread use of OCTA, no representative spatially rendered reference vessel surface area data are published. In this study, the OCTA vessel surface areas in 203 eyes of 107 healthy participants were measured in the 3D domain. A Generalized Linear Model (GLM) model analysis was performed to investigate the effects of sex, age, spherical equivalent, axial length, and visual acuity on the OCTA vessel surface area. The mean overall vessel surface area was 54.53 mm2 (range from 27.03 to 88.7 mm2). OCTA vessel surface area was slightly negatively correlated with age. However, the GLM model analysis identified axial length as having the strongest effect on OCTA vessel surface area. No significant correlations were found for sex or between left and right eyes. This is the first study to characterize three-dimensional vascular parameters in a population based on OCTA with respect to the vessel surface area

Standort
Deutsche Nationalbibliothek Frankfurt am Main
Umfang
Online-Ressource
Sprache
Englisch
Anmerkungen
Scientific Reports. - 12 (2022) , 3695, ISSN: 2045-2322

Ereignis
Veröffentlichung
(wo)
Freiburg
(wer)
Universität
(wann)
2022
Urheber
Maloca, Peter M.
Feu-Basilio, Silvia
Schottenhamml, Julia
Valmaggia, Philippe
Scholl, Hendrik Peter Nicolas
Rosinés-Fonoll, Josep
Marin-Martinez, Sara
Inglin, Nadja
Reich, Michael
Lange, Clemens
Egan, Catherine
Zweifel, Sandrine A.
Tufail, Adnan
Spaide, Richard F.
Zarranz-Ventura, Javier

DOI
10.1038/s41598-022-07439-2
URN
urn:nbn:de:bsz:25-freidok-2256069
Rechteinformation
Kein Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
Letzte Aktualisierung
25.03.2025, 13:48 MEZ

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  • 2022

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