Lack of structural brain alterations associated with insomnia: findings from the ENIGMA‐Sleep Working Group

Abstract: Existing neuroimaging studies have reported divergent structural alterations in insomnia disorder (ID). In the present study, we performed a large-scale coordinated meta-analysis by pooling structural brain measures from 1085 subjects (mean [SD] age 50.5 [13.9] years, 50.2% female, 17.4% with insomnia) across three international Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA)-Sleep cohorts. Two sites recruited patients with ID/controls: Freiburg (University of Freiburg Medical Center, Freiburg, Germany) 42/43 and KUMS (Kermanshah University of Medical Sciences, Kermanshah, Iran) 42/49, while the Study of Health in Pomerania (SHIP-Trend, University Medicine Greifswald, Greifswald, Germany) recruited population-based individuals with/without insomnia symptoms 75/662. The influence of insomnia on magnetic resonance imaging-based brain morphometry using an insomnia brain score was then assessed. Within each cohort, we used an ordinary least-squares linear regression to investigate the link between the individual regional cortical and subcortical volumes and the presence of insomnia symptoms. Then, we performed a fixed-effects meta-analysis across cohorts based on the first-level results. For the insomnia brain score, weighted logistic ridge regression was performed on one sample (Freiburg), which separated patients with ID from controls to train a model based on the segmentation measurements. Afterward, the insomnia brain scores were validated using the other two samples. The model was used to predict the log-odds of the subjects with insomnia given individual insomnia-related brain atrophy. After adjusting for multiple comparisons, we did not detect any significant associations between insomnia symptoms and cortical or subcortical volumes, nor could we identify a global insomnia-related brain atrophy pattern. Thus, we observed inconsistent brain morphology differences between individuals with and without insomnia across three independent cohorts. Further large-scale cross-sectional/longitudinal studies using both structural and functional neuroimaging are warranted to decipher the neurobiology of insomnia

Angaben zum Objekt

• Standort: Deutsche Nationalbibliothek Frankfurt am Main
• Umfang: Online-Ressource
• Sprache: Englisch
• Anmerkungen: Journal of sleep research. - 32, 5 (2023) , e13884, ISSN: 1365-2869

Beteiligte, Orts- und Zeitangaben

• Ereignis: Veröffentlichung
• (wo): Freiburg
• (wer): Universität
• (wann): 2023
• Urheber: Weihs, Antoine ; Frenzel, Stefan ; Bi, Hanwen ; Schiel, Julian E. ; Afshani, Mortaza ; Bülow, Robin ; Ewert, Ralf ; Fietze, Ingo ; Hoffstaedter, Felix ; Jahanshad, Neda ; Khazaie, Habibolah ; Riemann, Dieter ; Rostampour, Masoumeh ; Stubbe, Beate ; Thomopoulos, Sophia I. ; Thompson, Paul Murray ; Valk, Sofie Louise ; Völzke, Henry ; Zarei, Mojtaba ; Eickhoff, Simon Bodo Johannes ; Grabe, Hans Jörgen ; Patil, Kaustubh Raosaheb ; Spiegelhalder, Kai ; Tahmasian, Masoud

Weitere Informationen

• DOI: 10.1111/jsr.13884
• URN: urn:nbn:de:bsz:25-freidok-2351209
• Rechteinformation: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Letzte Aktualisierung: 25.03.2025, 13:51 MEZ