Aged mouse cortical microglia display an activation profile suggesting immunotolerogenic functions
Abstract: Microglia are the resident immune cells of the central nervous system (CNS) and participate in physiological and pathological processes. Their unique developmental nature suggests age-dependent structural and functional impairments that might contribute to neurodegenerative diseases. In the present study, we addressed the age-dependent changes in cortical microglia gene expression patterns and the expression of M1- and M2-like activation markers. Iba1 immunohistochemistry, isolation of cortical microglia followed by fluorescence-activated cell sorting and RNA isolation to analyze transcriptional changes in aged cortical microglia was performed. We provide evidence that aging is associated with decreased numbers of cortical microglia and the establishment of a distinct microglia activation profile including upregulation of Ifi204, Lilrb4, Arhgap, Oas1a, Cd244 and Ildr2. Moreover, flow cytometry revealed that aged cortical microglia express increased levels of Cd206 and Cd36. The data presented in the current study indicate that aged mouse cortical microglia adopt a distinct activation profile, which suggests immunosuppressive and immuno-tolerogenic functions
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Anmerkungen
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International journal of molecular sciences. 19, 3 (2018), article no. 706, DOI 10.3390/ijms19030706, issn: 2075-4450
- Schlagwort
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Mikroglia
Altern
Großhirnrinde
- Ereignis
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Veröffentlichung
- (wo)
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Freiburg
- (wer)
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Universität
- (wann)
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2018
- Urheber
- Beteiligte Personen und Organisationen
- DOI
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10.3390/ijms19030706
- URN
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urn:nbn:de:bsz:25-freidok-151449
- Rechteinformation
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Kein Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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14.08.2025, 10:48 MESZ
Datenpartner
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Zöller, Tanja
- Attaai, Abdelraheim
- Potru, Phani Sankar
- Ruß, Tamara
- Spittau, Björn
- Albert-Ludwigs-Universität Freiburg. Abteilung für Molekulare Embryologie
- Albert-Ludwigs-Universität Freiburg. Medizinische Fakultät
- Albert-Ludwigs-Universität Freiburg. Fakultät für Biologie
- Albert-Ludwigs-Universität Freiburg
- Universität
Entstanden
- 2018
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