Aged lipid‐laden microglia display impaired responses to stroke
Abstract: Microglial cells of the aged brain manifest signs of dysfunction that could contribute to the worse neurological outcome of stroke in the elderly. Treatment with colony‐stimulating factor 1 receptor antagonists enables transient microglia depletion that is followed by microglia repopulation after treatment interruption, causing no known harm to mice. We tested whether this strategy restored microglia function and ameliorated stroke outcome in old mice. Cerebral ischemia/reperfusion induced innate immune responses in microglia highlighted by type I interferon and metabolic changes involving lipid droplet biogenesis. Old microglia accumulated lipids under steady state and displayed exacerbated innate immune responses to stroke. Microglia repopulation in old mice reduced lipid‐laden microglia, and the cells exhibited reduced inflammatory responses to ischemia. Moreover, old mice with renewed microglia showed improved motor function 2 weeks after stroke. We conclude that lipid deposits in aged microglia impair the cellular responses to ischemia and worsen functional recovery in old mice.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Aged lipid‐laden microglia display impaired responses to stroke ; day:21 ; month:12 ; year:2022 ; extent:26
EMBO molecular medicine / European Molecular Biology Organization ; (21.12.2022) (gesamt 26)
- Creator
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Arbaizar‐Rovirosa, Maria
Pedragosa, Jordi
Lozano, Juan J.
Casal, Carme
Pol, Albert
Gallizioli, Mattia
Planas, Anna M.
- DOI
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10.15252/emmm.202217175
- URN
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urn:nbn:de:101:1-2022122114273506867342
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:24 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Arbaizar‐Rovirosa, Maria
- Pedragosa, Jordi
- Lozano, Juan J.
- Casal, Carme
- Pol, Albert
- Gallizioli, Mattia
- Planas, Anna M.
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