Occupational exposure to organic dust and risk of lymphoma subtypes in the EPILYMPH case-control study

Abstract: Objectives This study aimed to estimate the risk of lymphoma and its major subtypes in relation to occupational exposure to specific organic dusts.

Methods We explored the association in 1853 cases and 1997 controls who participated in the EpiLymph case–control study, conducted in six European countries in 1998–2004. Based on expert assessment of lifetime occupational exposures, we calculated the risk of the major lymphoma subtypes associated with exposure to six specific organic dusts, namely, flour, hardwood, softwood, natural textile, synthetic textile, and leather, and two generic (any types) groups: wood and textile dusts. Risk was predicted with unconditional regression modeling, adjusted by age, gender, study center, and education.

Results We observed a 2.1-fold increase in risk of follicular lymphoma associated with ever exposure to leather dust [95% confidence interval (CI) 1.01–4.20]. After excluding subjects who ever worked in a farm or had ever been exposed to solvents, risk of B-cell lymphoma was elevated in relation to ever exposure to leather dust [odd ratio (OR) 2.2, 95% CI 1.00–4.78], but it was not supported by increasing trends with the exposure metrics. Risk of Hodgkin lymphoma was elevated (OR 2.0, 95% CI 0.95–4.30) for exposure to textile dust, with consistent upward trends by cumulative exposure and three independent exposure metrics combined (P=0.023, and P=0.0068, respectively).

Conclusions Future, larger studies might provide further insights into the nature of the association we observed between exposure to textile dust and risk of Hodgkin lymphoma

Standort
Deutsche Nationalbibliothek Frankfurt am Main
Umfang
Online-Ressource
Sprache
Englisch
Anmerkungen
Scandinavian journal of work, environment & health. - 47, 1 (2021) , 42-51, ISSN: 1795-990X

Ereignis
Veröffentlichung
(wo)
Freiburg
(wer)
Universität
(wann)
2021
Urheber
Cocco, Pierluigi
Satta, Giannina
Meloni, Federico
Pilia, Ilaria
Ahmed, Fahad
Becker, Nikolaus
Casabonne, Delphine
Sanjosé, Silvia de
Foretová, Lenka
Maynadie, Marc
Mannetje, Andrea 't
Nieters, Alexandra
Staines, Anthony
Zucca, Mariagrazia
Ennas, Maria Grazia
Campagna, Marcello
Matteis, Sara de
Benavente, Yolanda

DOI
10.5271/sjweh.3925
URN
urn:nbn:de:bsz:25-freidok-1756937
Rechteinformation
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
Letzte Aktualisierung
25.03.2025, 13:45 MEZ

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  • 2021

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