Increased interictal synchronicity of respiratory related brain pulsations in epilepsy

Abstract: Respiratory brain pulsations have recently been shown to drive electrophysiological brain activity in patients with epilepsy. Furthermore, functional neuroimaging indicates that respiratory brain pulsations have increased variability and amplitude in patients with epilepsy compared to healthy individuals. To determine whether the respiratory drive is altered in epilepsy, we compared respiratory brain pulsation synchronicity between healthy controls and patients. Whole brain fast functional magnetic resonance imaging was performed on 40 medicated patients with focal epilepsy, 20 drug-naïve patients and 102 healthy controls. Cerebrospinal fluid associated respiratory pulsations were used to generate individual whole brain respiratory synchronization maps, which were compared between groups. Finally, we analyzed the seizure frequency effect and diagnostic accuracy of the respiratory synchronization defect in epilepsy. Respiratory brain pulsations related to the verified fourth ventricle pulsations were significantly more synchronous in patients in frontal, periventricular and mid-temporal regions, while the seizure frequency correlated positively with synchronicity. The respiratory brain synchronicity had a good diagnostic accuracy (ROCAUC = 0.75) in discriminating controls from medicated patients. The elevated respiratory brain synchronicity in focal epilepsy suggests altered physiological effect of cerebrospinal fluid pulsations possibly linked to regional brain water dynamics involved with interictal brain physiology

Location
Deutsche Nationalbibliothek Frankfurt am Main
Extent
Online-Ressource
Language
Englisch
Notes
Journal of cerebral blood flow & metabolism. - 42, 10 (2022) , 1840-1853, ISSN: 1559-7016

Event
Veröffentlichung
(where)
Freiburg
(who)
Universität
(when)
2022
Creator
Kananen, Janne
Järvelä, Matti
Korhonen, Vesa
Tuovinen, Timo
Huotari, Niko
Raitamaa, Lauri
Helakari, Heta
Väyrynen, Tommi
Raatikainen, Ville
Nedergaard, Maiken
Ansakorpi, Hanna
Jacobs-LeVan, Julia
LeVan, Pierre
Kiviniemi, Vesa

DOI
10.1177/0271678x221099703
URN
urn:nbn:de:bsz:25-freidok-2269877
Rights
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
Last update
25.03.2025, 1:51 PM CET

Data provider

This object is provided by:
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.

Associated

  • Kananen, Janne
  • Järvelä, Matti
  • Korhonen, Vesa
  • Tuovinen, Timo
  • Huotari, Niko
  • Raitamaa, Lauri
  • Helakari, Heta
  • Väyrynen, Tommi
  • Raatikainen, Ville
  • Nedergaard, Maiken
  • Ansakorpi, Hanna
  • Jacobs-LeVan, Julia
  • LeVan, Pierre
  • Kiviniemi, Vesa
  • Universität

Time of origin

  • 2022

Other Objects (12)