Ensheathing glia promote increased lifespan and healthy brain aging
Abstract: Glia have an emergent role in brain aging and disease. In the Drosophila melanogaster brain, ensheathing glia function as phagocytic cells and respond to acute neuronal damage, analogous to mammalian microglia. We previously reported changes in glia composition over the life of ants and fruit flies, including a decline in the relative proportion of ensheathing glia with time. How these changes influence brain health and life expectancy is unknown. Here, we show that ensheathing glia but not astrocytes decrease in number during Drosophila melanogaster brain aging. The remaining ensheathing glia display dysregulated expression of genes involved in lipid metabolism and apoptosis, which may lead to lipid droplet accumulation, cellular dysfunction, and death. Inhibition of apoptosis rescued the decline of ensheathing glia with age, improved the neuromotor performance of aged flies, and extended lifespan. Furthermore, an expanded ensheathing glia population prevented amyloid-beta accumulation in a fly model of Alzheimer's disease and delayed the premature death of the diseased animals. These findings suggest that ensheathing glia play a vital role in regulating brain health and animal longevity
- Standort
-
Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
-
Online-Ressource
- Sprache
-
Englisch
- Anmerkungen
-
Aging cell. - 22, 5 (2023) , e13803, ISSN: 1474-9726
- Ereignis
-
Veröffentlichung
- (wo)
-
Freiburg
- (wer)
-
Universität
- (wann)
-
2023
- Urheber
-
Sheng, Lihong
Shields, Emily J.
Gospocic, Janko
Sorida, Masato
Ju, Linyang
Byrns, China N.
Carranza, Faith
Berger, Shelley L
Bonini, Nancy M.
Bonasio, Roberto
- DOI
-
10.1111/acel.13803
- URN
-
urn:nbn:de:bsz:25-freidok-2347827
- Rechteinformation
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
-
25.03.2025, 13:42 MEZ
Datenpartner
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Sheng, Lihong
- Shields, Emily J.
- Gospocic, Janko
- Sorida, Masato
- Ju, Linyang
- Byrns, China N.
- Carranza, Faith
- Berger, Shelley L
- Bonini, Nancy M.
- Bonasio, Roberto
- Universität
Entstanden
- 2023
Ähnliche Objekte (12)
Long-term human spaceflight and inflammaging : Does it promote aging?
The aging decision maker: Investigating cognitive processes underlying decision making over the lifespan
Aging in a Digital World - Attitudes and Behaviors towards Technology Use Across the Life-Span
GLIA-GluR-channels
G (Glia-Grant) - H
Glia during de-and remyelination
Lower cortical thickness and increased brain aging in adults with cocaine use disorder
Polymer Nanopillars Induce Increased Paxillin Adhesion Assembly and Promote Axon Growth in Primary Cortical Neurons
Iron Homeostasis in Neuron-Glia Interaction
Neuron-glia interactions in neural plasticity
Glia cell reactions in viral encephalitis
The handbook of lifespan communication
Long-term human spaceflight and inflammaging : Does it promote aging?
The aging decision maker: Investigating cognitive processes underlying decision making over the lifespan
Aging in a Digital World - Attitudes and Behaviors towards Technology Use Across the Life-Span
GLIA-GluR-channels
G (Glia-Grant) - H
Glia during de-and remyelination
Lower cortical thickness and increased brain aging in adults with cocaine use disorder
Polymer Nanopillars Induce Increased Paxillin Adhesion Assembly and Promote Axon Growth in Primary Cortical Neurons
Iron Homeostasis in Neuron-Glia Interaction
Neuron-glia interactions in neural plasticity
Glia cell reactions in viral encephalitis
The handbook of lifespan communication
Long-term human spaceflight and inflammaging : Does it promote aging?
The aging decision maker: Investigating cognitive processes underlying decision making over the lifespan
Aging in a Digital World - Attitudes and Behaviors towards Technology Use Across the Life-Span
GLIA-GluR-channels
G (Glia-Grant) - H
Glia during de-and remyelination
Lower cortical thickness and increased brain aging in adults with cocaine use disorder
Polymer Nanopillars Induce Increased Paxillin Adhesion Assembly and Promote Axon Growth in Primary Cortical Neurons
Iron Homeostasis in Neuron-Glia Interaction
Neuron-glia interactions in neural plasticity
Glia cell reactions in viral encephalitis