Context-dependent function of TSLP and IL-1[beta] in skin allergic sensitization and atopic march
Abstract: Atopic diseases, including atopic dermatitis (AD) and asthma, affect a large proportion of the population, with increasing prevalence worldwide. AD often precedes the development of asthma, known as the atopic march. Allergen sensitization developed through the barrier-defective skin of AD has been recognized to be a critical step leading to asthma, in which thymic stromal lymphopoietin (TSLP) was previously shown to be critical. In this study, using a laser-assistant microporation system to disrupt targeted skin layers for generating micropores at a precise anatomic depth of mouse skin, we model allergen exposure superficially or deeply in the skin, leading to epicutaneous sensitization or dermacutaneous sensitization that is associated with a different cytokine microenvironment. Our work shows a differential requirement for TSLP in these two contexts, and identifies an important function for IL-1β, which is independent of TSLP, in promoting allergen sensitization and subsequent allergic asthma
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Anmerkungen
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Nature communications. - 13, 1 (2022) , 4703, ISSN: 2041-1723
- Ereignis
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Veröffentlichung
- (wo)
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Freiburg
- (wer)
-
Universität
- (wann)
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2022
- Urheber
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Segaud, Justine
Yao, Wenjin
Marschall, Pierre
Daubeuf, François
Lehalle, Christine
Germán, Beatriz
Meyer, Pierre
Hener, Pierre
Hugel, Cécile
Flatter, Eric
Guivarch, Marine
Clauss, Laetitia
Martin, Stefan F.
Oulad-Abdelghani, Mustapha
Li, Mei
- DOI
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10.1038/s41467-022-32196-1
- URN
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urn:nbn:de:bsz:25-freidok-2294778
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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25.03.2025, 13:49 MEZ
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Beteiligte
- Segaud, Justine
- Yao, Wenjin
- Marschall, Pierre
- Daubeuf, François
- Lehalle, Christine
- Germán, Beatriz
- Meyer, Pierre
- Hener, Pierre
- Hugel, Cécile
- Flatter, Eric
- Guivarch, Marine
- Clauss, Laetitia
- Martin, Stefan F.
- Oulad-Abdelghani, Mustapha
- Li, Mei
- Universität
Entstanden
- 2022
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