Context-dependent function of TSLP and IL-1[beta] in skin allergic sensitization and atopic march

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Abstract: Atopic diseases, including atopic dermatitis (AD) and asthma, affect a large proportion of the population, with increasing prevalence worldwide. AD often precedes the development of asthma, known as the atopic march. Allergen sensitization developed through the barrier-defective skin of AD has been recognized to be a critical step leading to asthma, in which thymic stromal lymphopoietin (TSLP) was previously shown to be critical. In this study, using a laser-assistant microporation system to disrupt targeted skin layers for generating micropores at a precise anatomic depth of mouse skin, we model allergen exposure superficially or deeply in the skin, leading to epicutaneous sensitization or dermacutaneous sensitization that is associated with a different cytokine microenvironment. Our work shows a differential requirement for TSLP in these two contexts, and identifies an important function for IL-1β, which is independent of TSLP, in promoting allergen sensitization and subsequent allergic asthma

Location
Deutsche Nationalbibliothek Frankfurt am Main
Extent
Online-Ressource
Language
Englisch
Notes
Nature communications. - 13, 1 (2022) , 4703, ISSN: 2041-1723

Event
Veröffentlichung
(where)
Freiburg
(who)
Universität
(when)
2022
Creator
Segaud, Justine
Yao, Wenjin
Marschall, Pierre
Daubeuf, François
Lehalle, Christine
Germán, Beatriz
Meyer, Pierre
Hener, Pierre
Hugel, Cécile
Flatter, Eric
Guivarch, Marine
Clauss, Laetitia
Martin, Stefan F.
Oulad-Abdelghani, Mustapha
Li, Mei

DOI
10.1038/s41467-022-32196-1
URN
urn:nbn:de:bsz:25-freidok-2294778
Rights
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
Last update
25.03.2025, 1:49 PM CET

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Associated

  • Segaud, Justine
  • Yao, Wenjin
  • Marschall, Pierre
  • Daubeuf, François
  • Lehalle, Christine
  • Germán, Beatriz
  • Meyer, Pierre
  • Hener, Pierre
  • Hugel, Cécile
  • Flatter, Eric
  • Guivarch, Marine
  • Clauss, Laetitia
  • Martin, Stefan F.
  • Oulad-Abdelghani, Mustapha
  • Li, Mei
  • Universität

Time of origin

  • 2022

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