RNA‐Templated Peptide Bond Formation Promotes L‐Homochirality
Abstract: The world in which we live is homochiral. The ribose units that form the backbone of DNA and RNA are all D‐configured and the encoded amino acids that comprise the proteins of all living species feature an all‐L‐configuration at the α‐carbon atoms. The homochirality of α‐amino acids is essential for folding of the peptides into well‐defined and functional 3D structures and the homochirality of D‐ribose is crucial for helix formation and base‐pairing. The question of why nature uses only encoded L‐α‐amino acids is not understood. Herein, we show that an RNA‐peptide world, in which peptides grow on RNAs constructed from D‐ribose, leads to the self‐selection of homo‐L‐peptides, which provides a possible explanation for the homo‐D‐ribose and homo‐L‐amino acid combination seen in nature.
- Standort
-
Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
-
Online-Ressource
- Sprache
-
Englisch
- Erschienen in
-
RNA‐Templated Peptide Bond Formation Promotes L‐Homochirality ; day:05 ; month:04 ; year:2024 ; extent:8
Angewandte Chemie / International edition. International edition ; (05.04.2024) (gesamt 8)
- Urheber
- DOI
-
10.1002/anie.202319235
- URN
-
urn:nbn:de:101:1-2024040614041388249830
- Rechteinformation
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
-
14.08.2025, 10:58 MESZ
Datenpartner
Dieses Objekt wird bereitgestellt von:
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Węgrzyn, Ewa
- Mejdrová, Ivana
- Müller, Felix M.
- Nainytė, Milda
- Escobar, Luis
- Carell, Thomas
Ähnliche Objekte (12)
Allenone-Mediated Formation of Peptide Bonds
Solar Radiation-Assisted Peptide-Bond Formation
Peptide Bond Formation by Using p-Nitrophenyl Esters
Photoredox Cobaloxime/Iridium Complex-Catalyzed Peptide-Bond Formation
Synthesis of hypermodified nucleosides and examination of nucleic acid templated stereoselective peptide formation in an RNA-peptide world
Peptide Bond Formation by Using 2-Pyridyl Thio Esters
The SecM arrest peptide traps a pre-peptide bond formation state of the ribosome
Copper-templated formation of dihelical oligothiophene-phenanthroline assemblies
Copper-Templated Formation of Dihelical Oligothiophene–Phenanthroline Assemblies
Peptide-templated acyl transfer as novel strategy for live cell imaging
Selective Activation of Peptide‐Thioester Precursors for Templated Native Chemical Ligations
Selective Activation of Peptide‐Thioester Precursors for Templated Native Chemical Ligations
Allenone-Mediated Formation of Peptide Bonds
Solar Radiation-Assisted Peptide-Bond Formation
Peptide Bond Formation by Using p-Nitrophenyl Esters
Photoredox Cobaloxime/Iridium Complex-Catalyzed Peptide-Bond Formation
Synthesis of hypermodified nucleosides and examination of nucleic acid templated stereoselective peptide formation in an RNA-peptide world
Peptide Bond Formation by Using 2-Pyridyl Thio Esters
The SecM arrest peptide traps a pre-peptide bond formation state of the ribosome
Copper-templated formation of dihelical oligothiophene-phenanthroline assemblies
Copper-Templated Formation of Dihelical Oligothiophene–Phenanthroline Assemblies
Peptide-templated acyl transfer as novel strategy for live cell imaging
Selective Activation of Peptide‐Thioester Precursors for Templated Native Chemical Ligations
Selective Activation of Peptide‐Thioester Precursors for Templated Native Chemical Ligations
Allenone-Mediated Formation of Peptide Bonds
Solar Radiation-Assisted Peptide-Bond Formation
Peptide Bond Formation by Using p-Nitrophenyl Esters
Photoredox Cobaloxime/Iridium Complex-Catalyzed Peptide-Bond Formation
Synthesis of hypermodified nucleosides and examination of nucleic acid templated stereoselective peptide formation in an RNA-peptide world
Peptide Bond Formation by Using 2-Pyridyl Thio Esters
The SecM arrest peptide traps a pre-peptide bond formation state of the ribosome
Copper-templated formation of dihelical oligothiophene-phenanthroline assemblies
Copper-Templated Formation of Dihelical Oligothiophene–Phenanthroline Assemblies
Peptide-templated acyl transfer as novel strategy for live cell imaging
Selective Activation of Peptide‐Thioester Precursors for Templated Native Chemical Ligations