RNA‐Templated Peptide Bond Formation Promotes L‐Homochirality
Abstract: The world in which we live is homochiral. The ribose units that form the backbone of DNA and RNA are all D‐configured and the encoded amino acids that comprise the proteins of all living species feature an all‐L‐configuration at the α‐carbon atoms. The homochirality of α‐amino acids is essential for folding of the peptides into well‐defined and functional 3D structures and the homochirality of D‐ribose is crucial for helix formation and base‐pairing. The question of why nature uses only encoded L‐α‐amino acids is not understood. Herein, we show that an RNA‐peptide world, in which peptides grow on RNAs constructed from D‐ribose, leads to the self‐selection of homo‐L‐peptides, which provides a possible explanation for the homo‐D‐ribose and homo‐L‐amino acid combination seen in nature.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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RNA‐Templated Peptide Bond Formation Promotes L‐Homochirality ; day:05 ; month:04 ; year:2024 ; extent:8
Angewandte Chemie / International edition. International edition ; (05.04.2024) (gesamt 8)
- Creator
- DOI
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10.1002/anie.202319235
- URN
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urn:nbn:de:101:1-2024040614041388249830
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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14.08.2025, 10:58 AM CEST
Data provider
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Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Węgrzyn, Ewa
- Mejdrová, Ivana
- Müller, Felix M.
- Nainytė, Milda
- Escobar, Luis
- Carell, Thomas
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