Enzymatic Synthesis of Diterpenoids from iso‐GGPP III: A Geranylgeranyl Diphosphate Analog with a Shifted Double Bond
Abstract: The analog of the diterpene precursor geranylgeranyl diphosphate with a double bond shifted from C14=C15 to C15=C16 (named iso‐GGPP III) has been synthesized and enzymatically converted with six bacterial diterpene synthases; this allowed the isolation of nine unnatural diterpenes. For some of the enzyme‐substrate combinations, the different reactivity implemented in the substrate analog iso‐GGPP III opened reaction pathways that are not observed with natural GGPP, resulting in the formation of diterpenes with novel skeletons. A stereoselective deuteration strategy was used to assign the absolute configurations of the isolated diterpenes.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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Enzymatic Synthesis of Diterpenoids from iso‐GGPP III: A Geranylgeranyl Diphosphate Analog with a Shifted Double Bond ; day:14 ; month:12 ; year:2023 ; extent:11
Chemistry - a European journal ; (14.12.2023) (gesamt 11)
- Urheber
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Li, Heng
Dickschat, Jeroen S.
- DOI
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10.1002/chem.202303560
- URN
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urn:nbn:de:101:1-2023121514164935810867
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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15.08.2025, 07:28 MESZ
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Beteiligte
- Li, Heng
- Dickschat, Jeroen S.
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