Biopolymer‐Based Nanogels Synthesis, Characterization, and Stability for Doxorubicin Encapsulation and Delivery

Abstract: Nanogels are nanostructures with dimensions within the nanoscale, composed of crosslinked polymers through their functional groups. Nanogels can display sensitiveness to stimuli, such as pH or temperature. This characteristic has been used in the design of new platforms for the transport and release of active ingredients. Biopolymer‐based nanogels are of great interest due to their biodegradability, biocompatibility, nontoxicity, and among others. In this project, pH‐responsive nanogels are synthesized through a novel methodology, using two polysaccharides classified as safe, biocompatible, and easily accessible materials, i.e., chitosan (CS) and maltodextrin (MD). A reductive amination reaction between CS and partially oxidized MDs allows to synthesized MD/CS nanogels with sizes ranging from 90 ± 5 to 194 ± 40 nm and with a colloidal stability up to 7 weeks. It is found that the variation of nanogels size and charge depends on CS concentration, molecular weight, and pH, as well as on the % oxidation of the MD. As evidence of nanogels pH‐responsiveness, an increase of size and ζ‐potential is observed by decreasing the pH. This size increase is attributed to the swelling of the nanogels upon a change in pH. Finally, doxorubicin is encapsulated in MD/CS nanogels, with a loading capacity up to 57%.

Standort
Deutsche Nationalbibliothek Frankfurt am Main
Umfang
Online-Ressource
Sprache
Englisch

Erschienen in
Biopolymer‐Based Nanogels Synthesis, Characterization, and Stability for Doxorubicin Encapsulation and Delivery ; volume:413 ; number:4 ; year:2024 ; extent:4
Macromolecular symposia ; 413, Heft 4 (2024) (gesamt 4)

Urheber
Fernández‐Solís, Karla Gricelda
González, Guillermo Toriz
Ochoa, Edgar Benjamín Figueroa
Rosselgong, Julien
Mijares, Eduardo Mendizabal
Bravo‐Anaya, Lourdes Mónica

DOI
10.1002/masy.202400114
URN
urn:nbn:de:101:1-2408171412187.643592093487
Rechteinformation
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
Letzte Aktualisierung
14.08.2025, 10:44 MESZ

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Beteiligte

  • Fernández‐Solís, Karla Gricelda
  • González, Guillermo Toriz
  • Ochoa, Edgar Benjamín Figueroa
  • Rosselgong, Julien
  • Mijares, Eduardo Mendizabal
  • Bravo‐Anaya, Lourdes Mónica

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