Nanogels with Selective Intracellular Reactivity for Intracellular Tracking and Delivery

Abstract: A multimodal approach for hydrogel‐based nanoparticles was developed to selectively allow molecular conjugated species to either be released inside the cell or remain connected to the polymer network. Using the intrinsic difference in reactivity between esters and amides, nanogels with an amide‐conjugated dye could be tracked intracellularly localizing next to the nucleus, while ester‐conjugation allowed for liberation of the molecular species from the hydrogel network inside the cell, enabling delivery throughout the cytoplasm. The release was a result of particle exposure to the intracellular environment. The conjugation approach and polymer network building rely on the same chemistry and provide a diverse range of possibilities to be used in nanomedicine and theranostic approaches.

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• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: Nanogels with Selective Intracellular Reactivity for Intracellular Tracking and Delivery ; volume:26 ; number:66 ; year:2020 ; pages:15084-15088 ; extent:5 ; Chemistry - a European journal ; 26, Heft 66 (2020), 15084-15088 (gesamt 5)

Contributors, Places and Time

• Creator: Zu, Guangyue ; Mergel, Olga ; Ribovski, Laís ; Bron, Reinier ; Zuhorn, Inge S. ; van Rijn, Patrick

Further information

• DOI: 10.1002/chem.202001802
• URN: urn:nbn:de:101:1-2022060313470830805613
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.