Bacterial toxins for cancer therapy
Abstract: Several pathogenic bacteria secrete toxins to inhibit the immune system of the infected organism. Frequently, they catalyze a covalent modification of specific proteins. Thereby, they block production and/or secretion of antibodies or cytokines. Moreover, they disable migration of macrophages and disturb the barrier function of epithelia. In most cases, these toxins are extremely effective enzymes with high specificity towards their cellular substrates, which are often central signaling molecules. Moreover, they encompass the capacity to enter mammalian cells and to modify their substrates in the cytosol. A few molecules, at least of some toxins, are sufficient to change the cellular morphology and function of a cell or even kill a cell. Since many of those toxins are well studied concerning molecular mechanisms, cellular receptors, uptake routes, and structures, they are now widely used to analyze or to influence specific signaling pathways of mammalian cells. Here, we review the development of immunotoxins and targeted toxins for the treatment of a disease that is still hard to treat: cancer
- Location
-
Deutsche Nationalbibliothek Frankfurt am Main
- Extent
-
Online-Ressource
- Language
-
Englisch
- Notes
-
Toxins. 9, 8 (2017), 236, DOI 10.3390/toxins9080236, issn: 2072-6651
IN COPYRIGHT http://rightsstatements.org/page/InC/1.0 rs
- Keyword
-
Bakteriengift
Krebs
Immunotoxin
Onkologie
- Event
-
Veröffentlichung
- (where)
-
Freiburg
- (who)
-
Universität
- (when)
-
2017
- Creator
- DOI
-
10.3390/toxins9080236
- URN
-
urn:nbn:de:bsz:25-freidok-131795
- Rights
-
Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
-
25.03.2025, 1:49 PM CET
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
Time of origin
- 2017
Other Objects (12)
Some examples of bacterial toxins as tools
Targeted toxins for the treatment of prostate cancer
Bacterial protein toxins
Pharmacology of bacterial toxins
Environmental toxicology : non-bacterial toxins
MicroRNAs in cancer translational research: the microcosm of cancer diagnosis, prognosis, and therapy
From signal transduction to protein toxins - a narrative review about milestones on the research route of C. difficile toxins
Another surprise in receptor binding of C. difficile toxins
Improving gastrointestinal cancer therapy by uniting stakeholders
Study of the membrane interaction of bacterial toxins
Structural investigation of cholesterol homeostasis and bacterial toxins
Bacterial toxins : tools in cell biology and pharmacology
Some examples of bacterial toxins as tools
Targeted toxins for the treatment of prostate cancer
Bacterial protein toxins
Pharmacology of bacterial toxins
Environmental toxicology : non-bacterial toxins
MicroRNAs in cancer translational research: the microcosm of cancer diagnosis, prognosis, and therapy
From signal transduction to protein toxins - a narrative review about milestones on the research route of C. difficile toxins
Another surprise in receptor binding of C. difficile toxins
Improving gastrointestinal cancer therapy by uniting stakeholders
Study of the membrane interaction of bacterial toxins
Structural investigation of cholesterol homeostasis and bacterial toxins
Bacterial toxins : tools in cell biology and pharmacology
Some examples of bacterial toxins as tools
Targeted toxins for the treatment of prostate cancer
Bacterial protein toxins
Pharmacology of bacterial toxins
Environmental toxicology : non-bacterial toxins
MicroRNAs in cancer translational research: the microcosm of cancer diagnosis, prognosis, and therapy
From signal transduction to protein toxins - a narrative review about milestones on the research route of C. difficile toxins
Another surprise in receptor binding of C. difficile toxins
Improving gastrointestinal cancer therapy by uniting stakeholders
Study of the membrane interaction of bacterial toxins
Structural investigation of cholesterol homeostasis and bacterial toxins