The GRADE Working Group clarifies the construct of certainty of evidence
Abstract: Objective
To clarify the grading of recommendations assessment, development and evaluation (GRADE) definition of certainty of evidence and suggest possible approaches to rating certainty of the evidence for systematic reviews, health technology assessments, and guidelines.
Study Design and Setting
This work was carried out by a project group within the GRADE Working Group, through brainstorming and iterative refinement of ideas, using input from workshops, presentations, and discussions at GRADE Working Group meetings to produce this document, which constitutes official GRADE guidance.
Results
Certainty of evidence is best considered as the certainty that a true effect lies on one side of a specified threshold or within a chosen range. We define possible approaches for choosing threshold or range. For guidelines, what we call a fully contextualized approach requires simultaneously considering all critical outcomes and their relative value. Less-contextualized approaches, more appropriate for systematic reviews and health technology assessments, include using specified ranges of magnitude of effect, for example, ranges of what we might consider no effect, trivial, small, moderate, or large effects.
Conclusion
It is desirable for systematic review authors, guideline panelists, and health technology assessors to specify the threshold or ranges they are using when rating the certainty in evidence
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Notes
-
Journal of clinical epidemiology. - 87 (2017) , 4-13, ISSN: 1878-5921
- Event
-
Veröffentlichung
- (where)
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Freiburg
- (who)
-
Universität
- (when)
-
2024
- Creator
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Hultcrantz, Monica
Rind, David
Akl, Elie A.
Treweek, Shaun
Mustafa, Reem A.
Iorio, Alfonso
Alper, Brian S
Meerpohl, Jörg J.
Murad, M. Hassan
Ansari, Mohammed Toseef
Katikireddi, Srinivasa Vittal
Östlund, Pernilla
Tranæus, Sofia
Christensen, Robin
Gartlehner, Gerald
Brożek, Jan L.
Izcovich, Ariel
Schünemann, Holger J.
Guyatt, Gordon
- DOI
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10.1016/j.jclinepi.2017.05.006
- URN
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urn:nbn:de:bsz:25-freidok-1385014
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:29 AM CEST
Data provider
This object is provided by:
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Hultcrantz, Monica
- Rind, David
- Akl, Elie A.
- Treweek, Shaun
- Mustafa, Reem A.
- Iorio, Alfonso
- Alper, Brian S
- Meerpohl, Jörg J.
- Murad, M. Hassan
- Ansari, Mohammed Toseef
- Katikireddi, Srinivasa Vittal
- Östlund, Pernilla
- Tranæus, Sofia
- Christensen, Robin
- Gartlehner, Gerald
- Brożek, Jan L.
- Izcovich, Ariel
- Schünemann, Holger J.
- Guyatt, Gordon
- Universität
Time of origin
- 2024
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