The GRADE Working Group clarifies the construct of certainty of evidence
Abstract: Objective
To clarify the grading of recommendations assessment, development and evaluation (GRADE) definition of certainty of evidence and suggest possible approaches to rating certainty of the evidence for systematic reviews, health technology assessments, and guidelines.
Study Design and Setting
This work was carried out by a project group within the GRADE Working Group, through brainstorming and iterative refinement of ideas, using input from workshops, presentations, and discussions at GRADE Working Group meetings to produce this document, which constitutes official GRADE guidance.
Results
Certainty of evidence is best considered as the certainty that a true effect lies on one side of a specified threshold or within a chosen range. We define possible approaches for choosing threshold or range. For guidelines, what we call a fully contextualized approach requires simultaneously considering all critical outcomes and their relative value. Less-contextualized approaches, more appropriate for systematic reviews and health technology assessments, include using specified ranges of magnitude of effect, for example, ranges of what we might consider no effect, trivial, small, moderate, or large effects.
Conclusion
It is desirable for systematic review authors, guideline panelists, and health technology assessors to specify the threshold or ranges they are using when rating the certainty in evidence
- Standort
-
Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
-
Online-Ressource
- Sprache
-
Englisch
- Anmerkungen
-
Journal of clinical epidemiology. - 87 (2017) , 4-13, ISSN: 1878-5921
- Ereignis
-
Veröffentlichung
- (wo)
-
Freiburg
- (wer)
-
Universität
- (wann)
-
2024
- Urheber
-
Hultcrantz, Monica
Rind, David
Akl, Elie A.
Treweek, Shaun
Mustafa, Reem A.
Iorio, Alfonso
Alper, Brian S
Meerpohl, Jörg J.
Murad, M. Hassan
Ansari, Mohammed Toseef
Katikireddi, Srinivasa Vittal
Östlund, Pernilla
Tranæus, Sofia
Christensen, Robin
Gartlehner, Gerald
Brożek, Jan L.
Izcovich, Ariel
Schünemann, Holger J.
Guyatt, Gordon
- DOI
-
10.1016/j.jclinepi.2017.05.006
- URN
-
urn:nbn:de:bsz:25-freidok-1385014
- Rechteinformation
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
-
15.08.2025, 07:29 MESZ
Datenpartner
Dieses Objekt wird bereitgestellt von:
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Hultcrantz, Monica
- Rind, David
- Akl, Elie A.
- Treweek, Shaun
- Mustafa, Reem A.
- Iorio, Alfonso
- Alper, Brian S
- Meerpohl, Jörg J.
- Murad, M. Hassan
- Ansari, Mohammed Toseef
- Katikireddi, Srinivasa Vittal
- Östlund, Pernilla
- Tranæus, Sofia
- Christensen, Robin
- Gartlehner, Gerald
- Brożek, Jan L.
- Izcovich, Ariel
- Schünemann, Holger J.
- Guyatt, Gordon
- Universität
Entstanden
- 2024
Ähnliche Objekte (12)
Improving the trustworthiness of findings from nutrition evidence syntheses: assessing risk of bias and rating the certainty of evidence
Improving the trustworthiness of findings from nutrition evidence syntheses: assessing risk of bias and rating the certainty of evidence
Good or best practice statements: proposal for the operationalisation and implementation of GRADE guidance
Which actionable statements qualify as good practice statements In Covid-19 guidelines? : : a systematic appraisal
Using patient values and preferences to inform the importance of health outcomes in practice guideline development following the GRADE approach
GRADE evidence to decision (EtD) frameworks for adoption, adaptation, and de novo development of trustworthy recommendations: GRADE-ADOLOPMENT
Der Kohlendioxidtransport im Organismus : Untersuchungen zur Kinetik des pulmonalen CO2-Austauschs und zum Einfluss des Laktats auf das oxylabile CO2
Wissenschaftliche Publikationspraxis in der klinischen Medizin : Wissenstransfer als Voraussetzung für evidenzbasierte Medizin
Defining certainty of net benefit: a GRADE concept paper
GRADE equity guidelines 3: considering health equity in GRADE guideline development: rating the certainty of synthesized evidence
American Society of Hematology living guidelines on the use of anticoagulation for thromboprophylaxis in patients with COVID-19: May 2021 update on the use of intermediate-intensity anticoagulation in critically ill patients
American Society of Hematology living guidelines on the use of anticoagulation for thromboprophylaxis in patients with COVID-19: January 2022 update on the use of therapeutic-intensity anticoagulation in acutely ill patients
Improving the trustworthiness of findings from nutrition evidence syntheses: assessing risk of bias and rating the certainty of evidence
Improving the trustworthiness of findings from nutrition evidence syntheses: assessing risk of bias and rating the certainty of evidence
Good or best practice statements: proposal for the operationalisation and implementation of GRADE guidance
Which actionable statements qualify as good practice statements In Covid-19 guidelines? : : a systematic appraisal
Using patient values and preferences to inform the importance of health outcomes in practice guideline development following the GRADE approach
GRADE evidence to decision (EtD) frameworks for adoption, adaptation, and de novo development of trustworthy recommendations: GRADE-ADOLOPMENT
Der Kohlendioxidtransport im Organismus : Untersuchungen zur Kinetik des pulmonalen CO2-Austauschs und zum Einfluss des Laktats auf das oxylabile CO2
Wissenschaftliche Publikationspraxis in der klinischen Medizin : Wissenstransfer als Voraussetzung für evidenzbasierte Medizin
Defining certainty of net benefit: a GRADE concept paper
GRADE equity guidelines 3: considering health equity in GRADE guideline development: rating the certainty of synthesized evidence
American Society of Hematology living guidelines on the use of anticoagulation for thromboprophylaxis in patients with COVID-19: May 2021 update on the use of intermediate-intensity anticoagulation in critically ill patients
American Society of Hematology living guidelines on the use of anticoagulation for thromboprophylaxis in patients with COVID-19: January 2022 update on the use of therapeutic-intensity anticoagulation in acutely ill patients
Improving the trustworthiness of findings from nutrition evidence syntheses: assessing risk of bias and rating the certainty of evidence
Improving the trustworthiness of findings from nutrition evidence syntheses: assessing risk of bias and rating the certainty of evidence
Good or best practice statements: proposal for the operationalisation and implementation of GRADE guidance
Which actionable statements qualify as good practice statements In Covid-19 guidelines? : : a systematic appraisal
Using patient values and preferences to inform the importance of health outcomes in practice guideline development following the GRADE approach
GRADE evidence to decision (EtD) frameworks for adoption, adaptation, and de novo development of trustworthy recommendations: GRADE-ADOLOPMENT
Der Kohlendioxidtransport im Organismus : Untersuchungen zur Kinetik des pulmonalen CO2-Austauschs und zum Einfluss des Laktats auf das oxylabile CO2
Wissenschaftliche Publikationspraxis in der klinischen Medizin : Wissenstransfer als Voraussetzung für evidenzbasierte Medizin
Defining certainty of net benefit: a GRADE concept paper
GRADE equity guidelines 3: considering health equity in GRADE guideline development: rating the certainty of synthesized evidence
American Society of Hematology living guidelines on the use of anticoagulation for thromboprophylaxis in patients with COVID-19: May 2021 update on the use of intermediate-intensity anticoagulation in critically ill patients