Maintaining proteostasis under mechanical stress
Abstract: Cell survival, tissue integrity and organismal health depend on the ability to maintain functional protein networks even under conditions that threaten protein integrity. Protection against such stress conditions involves the adaptation of folding and degradation machineries, which help to preserve the protein network by facilitating the refolding or disposal of damaged proteins. In multicellular organisms, cells are permanently exposed to stress resulting from mechanical forces. Yet, for long time mechanical stress was not recognized as a primary stressor that perturbs protein structure and threatens proteome integrity. The identification and characterization of protein folding and degradation systems, which handle force-unfolded proteins, marks a turning point in this regard. It has become apparent that mechanical stress protection operates during cell differentiation, adhesion and migration and is essential for maintaining tissues such as skeletal muscle, heart and kidney as well as the immune system. Here, we provide an overview of recent advances in our understanding of mechanical stress protection
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Anmerkungen
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EMBO reports. - 22, 8 (2021) , e52507, ISSN: 1469-3178
- Ereignis
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Veröffentlichung
- (wo)
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Freiburg
- (wer)
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Universität
- (wann)
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2021
- Urheber
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Höhfeld, Jörg
Benzing, Thomas
Bloch, Wilhelm
Fürst, Dieter O.
Gehlert, Sebastian
Hesse, Michael
Hoffmann, Bernd
Hoppe, Thorsten
Huesgen, Pitter Florian
Köhn, Maja
Kolanus, Waldemar
Merkel, Rudolf
Niessen, Carien M.
Pokrzywa, Wojciech
Rinschen, Markus Matthias
Wachten, Dagmar
Warscheid, Bettina
- Beteiligte Personen und Organisationen
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Abteilung Integrative Signalforschung
- DOI
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10.15252/embr.202152507
- URN
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urn:nbn:de:bsz:25-freidok-2210329
- Rechteinformation
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Kein Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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25.03.2025, 13:44 MEZ
Datenpartner
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Höhfeld, Jörg
- Benzing, Thomas
- Bloch, Wilhelm
- Fürst, Dieter O.
- Gehlert, Sebastian
- Hesse, Michael
- Hoffmann, Bernd
- Hoppe, Thorsten
- Huesgen, Pitter Florian
- Köhn, Maja
- Kolanus, Waldemar
- Merkel, Rudolf
- Niessen, Carien M.
- Pokrzywa, Wojciech
- Rinschen, Markus Matthias
- Wachten, Dagmar
- Warscheid, Bettina
- Abteilung Integrative Signalforschung
- Universität
Entstanden
- 2021
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