Maintaining proteostasis under mechanical stress

Abstract: Cell survival, tissue integrity and organismal health depend on the ability to maintain functional protein networks even under conditions that threaten protein integrity. Protection against such stress conditions involves the adaptation of folding and degradation machineries, which help to preserve the protein network by facilitating the refolding or disposal of damaged proteins. In multicellular organisms, cells are permanently exposed to stress resulting from mechanical forces. Yet, for long time mechanical stress was not recognized as a primary stressor that perturbs protein structure and threatens proteome integrity. The identification and characterization of protein folding and degradation systems, which handle force-unfolded proteins, marks a turning point in this regard. It has become apparent that mechanical stress protection operates during cell differentiation, adhesion and migration and is essential for maintaining tissues such as skeletal muscle, heart and kidney as well as the immune system. Here, we provide an overview of recent advances in our understanding of mechanical stress protection

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch
• Notes: EMBO reports. - 22, 8 (2021) , e52507, ISSN: 1469-3178

Contributors, Places and Time

• Event: Veröffentlichung
• (where): Freiburg
• (who): Universität
• (when): 2021
• Creator: Höhfeld, Jörg ; Benzing, Thomas ; Bloch, Wilhelm ; Fürst, Dieter O. ; Gehlert, Sebastian ; Hesse, Michael ; Hoffmann, Bernd ; Hoppe, Thorsten ; Huesgen, Pitter F. ; Köhn, Maja ; Kolanus, Waldemar ; Merkel, Rudolf ; Niessen, Carien M. ; Pokrzywa, Wojciech ; Rinschen, Markus Matthias ; Wachten, Dagmar ; Warscheid, Bettina
• Contributor: Abteilung Integrative Signalforschung

Further information

• DOI: 10.15252/embr.202152507
• URN: urn:nbn:de:bsz:25-freidok-2210329
• Rights: Kein Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 15.08.2025, 7:23 AM CEST