Effects of Exercise-Induced Changes in Myokine Expression on the Tumor Microenvironment

Abstract: In this narrative review, we summarize the direct and indirect effects that myokines have on the tumor microenvironment. We took studies of various cancer types and species into account. Systematic reviews and meta-analyses that matched the search terms were also considered. We searched databases for six months. As a narrative approach was chosen, no data was analyzed or reanalyzed. The goal of this narrative review is to create an overview on the topic to identify research gaps and answer the questions as to whether myokine expression may be relevant in cancer research in regard to the tumor microenvironment. Six commonly known myokines were chosen. We found strong links between the influence exercise has on interleukin-6, oncostatin M, secreted protein acidic and rich in cysteine, and irisin in the context of tumor progression and inhibition via interactions with the tumor microenvironment. It became clear that the effects of myokines on the tumor microenvironment can vary and contribute to disease progression or regression. Interactions among myokines and immune cells must also be considered and require further investigation. To date, no study has shown a clear connection, while multiple studies suggest further investigation of the topic, similar to the effects of exercise on myokine expression.

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: Effects of Exercise-Induced Changes in Myokine Expression on the Tumor Microenvironment ; volume:08 ; number:CP ; year:2024 ; Sports medicine international open ; 08, Heft CP (2024)

Contributors, Places and Time

• Contributor: Gunasekara, Nadira ; Clauss, Dorothea ; Bloch, Wilhelm

Further information

• DOI: 10.1055/a-2283-1663
• URN: urn:nbn:de:101:1-2408081009122.621051069910
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 14.08.2025, 10:52 AM CEST