MutaRNA: analysis and visualization of mutation-induced changes in RNA structure
Abstract: RNA molecules fold into complex structures as a result of intramolecular interactions between their nucleotides. The function of many non-coding RNAs and some cis-regulatory elements of messenger RNAs highly depends on their fold. Single-nucleotide variants (SNVs) and other types of mutations can disrupt the native function of an RNA element by altering its base pairing pattern. Identifying the effect of a mutation on an RNA’s structure is, therefore, a crucial step in evaluating the impact of mutations on the post-transcriptional regulation and function of RNAs within the cell. Even though a single nucleotide variation can have striking impacts on the structure formation, interpreting and comparing the impact usually needs expertise and meticulous efforts. Here, we present MutaRNA, a web server for visualization and interpretation of mutation-induced changes on the RNA structure in an intuitive and integrative fashion. To this end, probabilities of base pairing and position-wise unpaired probabilities of wildtype and mutated RNA sequences are computed and compared. Differential heatmap-like dot plot representations in combination with circular plots and arc diagrams help to identify local structure abberations, which are otherwise hidden in standard outputs. Eventually, MutaRNA provides a comprehensive and comparative overview of the mutation-induced changes in base pairing potentials and accessibility. The MutaRNA web server is freely available at http://rna.informatik.uni-freiburg.de/MutaRNA
- Standort
-
Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
-
Online-Ressource
- Sprache
-
Englisch
- Anmerkungen
-
Nucleic acids research. - 48, W1 (2020) , W287-W291, ISSN: 1362-4962
- Ereignis
-
Veröffentlichung
- (wo)
-
Freiburg
- (wer)
-
Universität
- (wann)
-
2020
- DOI
-
10.1093/nar/gkaa331
- URN
-
urn:nbn:de:bsz:25-freidok-1662131
- Rechteinformation
-
Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
-
25.03.2025, 13:47 MEZ
Datenpartner
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Miladi, Milad
- Raden, Martin
- Diederichs, Sven
- Backofen, Rolf
- Universität
Entstanden
- 2020
Ähnliche Objekte (12)
Computational analysis and prediction of RNA-RNA interactions : = Computergestützte Analyse und Vorhersage von RNA-RNA-Interaktionen
INFO-RNA—a server for fast inverse RNA folding satisfying sequence constraints
Using local RNA secondary structures for computational comparison and clustering of RNA molecules
Expressivity and decidability of first-order languages over feature trees
Expressivity and decidability of first-order languages over feature trees
CMV: visualization for RNA and protein family models and their comparisons
IntaRNA 2.0: enhanced and customizable prediction of RNA–RNA interactions
Ant colony optimization based inverse folding of mono- and bistable RNA macromolecules
Interactive implementations of thermodynamics-based RNA structure and RNA–RNA interaction prediction approaches for example-driven teaching
Integration of accessibility data from structure probing into RNA–RNA interaction prediction
CopomuS - ranking compensatory mutations to guide RNA-RNA interaction verification experiments
CRISPRtracrRNA: robust approach for CRISPR tracrRNA detection
Computational analysis and prediction of RNA-RNA interactions : = Computergestützte Analyse und Vorhersage von RNA-RNA-Interaktionen
INFO-RNA—a server for fast inverse RNA folding satisfying sequence constraints
Using local RNA secondary structures for computational comparison and clustering of RNA molecules
Expressivity and decidability of first-order languages over feature trees
Expressivity and decidability of first-order languages over feature trees
CMV: visualization for RNA and protein family models and their comparisons
IntaRNA 2.0: enhanced and customizable prediction of RNA–RNA interactions
Ant colony optimization based inverse folding of mono- and bistable RNA macromolecules
Interactive implementations of thermodynamics-based RNA structure and RNA–RNA interaction prediction approaches for example-driven teaching
Integration of accessibility data from structure probing into RNA–RNA interaction prediction
CopomuS - ranking compensatory mutations to guide RNA-RNA interaction verification experiments
CRISPRtracrRNA: robust approach for CRISPR tracrRNA detection
Computational analysis and prediction of RNA-RNA interactions : = Computergestützte Analyse und Vorhersage von RNA-RNA-Interaktionen
INFO-RNA—a server for fast inverse RNA folding satisfying sequence constraints
Using local RNA secondary structures for computational comparison and clustering of RNA molecules
Expressivity and decidability of first-order languages over feature trees
Expressivity and decidability of first-order languages over feature trees
CMV: visualization for RNA and protein family models and their comparisons
IntaRNA 2.0: enhanced and customizable prediction of RNA–RNA interactions
Ant colony optimization based inverse folding of mono- and bistable RNA macromolecules
Interactive implementations of thermodynamics-based RNA structure and RNA–RNA interaction prediction approaches for example-driven teaching
Integration of accessibility data from structure probing into RNA–RNA interaction prediction
CopomuS - ranking compensatory mutations to guide RNA-RNA interaction verification experiments