Fabrication of embedded microfluidic chips with single micron resolution using two‐photon lithography
Abstract: Two-photon lithography (TPL) is an advanced high-resolution additive manufacturing technique for objects with feature sizes between 100 nanometers to tens of micrometers and an overall footprint of up to hundreds of micrometers. With recent advances in the TPL technique, writing speeds are becoming faster, rendering the method feasible to print high-resolution microfluidic chips with a footprint in the centimeter range within a reasonable time frame. In this work, a process flow to fabricate embedded microfluidic chips with channel diameters down to 30 µm is developed. To address the particular difficulty of washing the embedded channels free of uncured material, introduces a developing scheme based on a 3D printed chip-to-world-interface to connect the chips to a pressure-driven pump. This setup is leakage-free up to a pressure of 6.9 bar for faster and safer development of embedded microfluidic devices. It manufactures meander chips with channel lengths up to 20 cm, droplet generator chips, and cell sorting chips based on deterministic lateral displacement with pillar diameters of 30 µm and pillar spacing of 4 µm. TPL of microfluidic chips will enable rapid manufacturing of novel designs, significantly reducing concept-to-chip times with high resolution in a reasonable amount of time
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Notes
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Advanced materials technologies. - 8, 22 (2023) , 2300667, ISSN: 2365-709X
- Event
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Veröffentlichung
- (where)
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Freiburg
- (who)
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Universität
- (when)
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2023
- Creator
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Luitz, Manuel
Kırpat Konak, Büşra M.
Sherbaz, Ahmad
Prediger, Richard
Nekoonam, Niloofar
Di Ventura, Barbara
Kotz-Helmer, Frederik
Rapp, Bastian E.
- DOI
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10.1002/admt.202300667
- URN
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urn:nbn:de:bsz:25-freidok-2403004
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:35 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Luitz, Manuel
- Kırpat Konak, Büşra M.
- Sherbaz, Ahmad
- Prediger, Richard
- Nekoonam, Niloofar
- Di Ventura, Barbara
- Kotz-Helmer, Frederik
- Rapp, Bastian E.
- Universität
Time of origin
- 2023
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Two‐Photon Direct Laser Writing of 3D Scaffolds through C, H‐Insertion Crosslinking in a One‐Component Material System
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Substrate-independent maskless writing of functionalized microstructures using CHic chemistry and digital light processing
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Fabrication of Embedded Microfluidic Chips with Single Micron Resolution Using Two‐Photon Lithography
Scanning‐Laser‐Based Microstereolithography of Microfluidic Chips with Micron Resolution
Two‐Photon Direct Laser Writing of 3D Scaffolds through C, H‐Insertion Crosslinking in a One‐Component Material System
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Highly fluorinated methacrylates for optical 3D printing of microfluidic devices
Analytical solution of the time-dependent microfluidic poiseuille flow in rectangular channel cross-sections and its numerical implementation in microsoft excel
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