Sine ventilation in lung injury models: a new perspective for lung protective ventilation

zu Verbundenen Objekten

Abstract: Mechanical ventilation is associated with the risk of ventilator induced lung injury. For reducing lung injury in mechanically ventilated patients, the application of small tidal volumes and positive end-expiratory pressures has become clinical standard. Recently, an approach based on linear airway pressure decline and decelerated expiratory flow during expiration implied lung protective capacities. We assumed that ventilation with a smoothed, i.e. sinusoidal airway pressure profile may further improve ventilation efficiency and lung protection. We compared the effects of mechanical ventilation with sinusoidal airway pressure profile (SINE) regarding gas exchange, respiratory system compliance and histology to conventional volume and pressure controlled ventilation (VCV and PCV) and to VCV with flow-controlled expiration (FLEX) in two rat models of lung injury, tween induced surfactant depletion and high tidal volume mechanical ventilation. In both lung injury models ventilation with SINE showed more efficient CO2 elimination and blood oxygenation, improved respiratory system compliance and resulted in lower alveolar wall thickness, compared to VCV, PCV and FLEX. Optimization of the airway pressure profile may provide a novel means of lung protective mechanical ventilation

Standort
Deutsche Nationalbibliothek Frankfurt am Main
Umfang
Online-Ressource
Sprache
Englisch
Anmerkungen
Scientific reports. - 10, 1 (2020) , 11690, ISSN: 2045-2322

Ereignis
Veröffentlichung
(wo)
Freiburg
(wer)
Universität
(wann)
2020
Urheber
Spassov, Sashko G.
Wenzel, Christin
Lozano-Zahonero, Sara
Boycheva, Dimona
Streicher, Lea
Schmidt, Johannes
Schumann, Stefan

DOI
10.1038/s41598-020-68614-x
URN
urn:nbn:de:bsz:25-freidok-1667232
Rechteinformation
Der Zugriff auf das Objekt ist unbeschränkt möglich.
Letzte Aktualisierung
25.03.2025, 13:53 MEZ

Datenpartner

Dieses Objekt wird bereitgestellt von:
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Original beim Datenpartner anzeigen

Beteiligte

Entstanden

  • 2020

Ähnliche Objekte (12)

Hepatic effects of lung protective pressure controlled ventilation and a combination of high frequency oscillatory ventilation and extracorporeal lung assist in experimental lung injury

Hepatic effects of lung protective pressure controlled ventilation and a combination of high frequency oscillatory ventilation and extracorporeal lung assist in experimental lung injury

Lung-protective ventilation attenuates mechanical injury while hypercapnia attenuates biological injury in a rat model of ventilator-associated lung injury

Lung-protective ventilation attenuates mechanical injury while hypercapnia attenuates biological injury in a rat model of ventilator-associated lung injury

Flow-controlled ventilation improves gas exchange in lung-healthy patients – a randomised interventional cross-over study

Flow-controlled ventilation improves gas exchange in lung-healthy patients – a randomised interventional cross-over study

Protective signalling mechanisms in the lung induced by open-lung ventilation strategies

Hochschulschrift

Protective signalling mechanisms in the lung induced by open-lung ventilation strategies

Protective signalling mechanisms in the lung induced by open-lung ventilation strategies

Hochschulschrift

Protective signalling mechanisms in the lung induced by open-lung ventilation strategies

Mechanismen der Knochenheilung und deren Regulation durch Glykosaminoglykane

Hochschulschrift

Mechanismen der Knochenheilung und deren Regulation durch Glykosaminoglykane

Die Antike im Leben und Schaffen Christoph Wilhelm Hufelands

Hochschulschrift

Die Antike im Leben und Schaffen Christoph Wilhelm Hufelands

Anabelian aspects in the étale homotopy theory of Brauer-Severi varieties

Hochschulschrift

Anabelian aspects in the étale homotopy theory of Brauer-Severi varieties

[Stammbuch Johannes Schmidt] ; Omnia D. And. Alciati Emblemata : Ad Qvae Singvla, Praeter concinnas acutásque inscriptiones, lepidas & expressas imagines, ac cætera omnia, quæ prioribus nostris editionibus cùm ad eorum distinctionem, tum ad ornatum & correctionem adhibita continebantur, Nunc primùm perelegantia persubtiliaq[ue] adiecta sunt Epimythia, quibus Emblematum amplitudo, & quæcunque in ijs dubia sunt aut obscura tanquam perspicuis illustrantur

Handschrift

[Stammbuch Johannes Schmidt] ; Omnia D. And. Alciati Emblemata : Ad Qvae Singvla, Praeter concinnas acutásque inscriptiones, lepidas & expressas imagines, ac cætera omnia, quæ prioribus nostris editionibus cùm ad eorum distinctionem, tum ad ornatum & correctionem adhibita continebantur, Nunc primùm perelegantia persubtiliaq[ue] adiecta sunt Epimythia, quibus Emblematum amplitudo, & quæcunque in ijs dubia sunt aut obscura tanquam perspicuis illustrantur

Blutdruckverhalten nach verschiedenen Therapieformen bei Nierensteinen

Hochschulschrift

Blutdruckverhalten nach verschiedenen Therapieformen bei Nierensteinen

Pharmakologische Studien über einige neue Falicainderivate

Hochschulschrift

Pharmakologische Studien über einige neue Falicainderivate

Wohnhaus; Berlin, Friedrichshain-Kreuzberg

Wohnhaus

Wohnhaus; Berlin, Friedrichshain-Kreuzberg

Verbundene Objekte