Promising biocompatible hydrogels of crosslinked polyelectrolytes for biomedical applications

Abstract: For the development of intelligent implant systems hydrogels (HG) from crosslinked ionic liquids feature a high potential to be utilised as a drug depot. Biocompatibility of the HGs is one key prerequisite for biomedical applications. HGs were polymerised from a variety of different ionic monomers based on methacrylate, methacrylamide, styrene or vinyl imidazolium derivatives in aqueous solution. N,N'-methylenebisacrylamide was used as crosslinker. CellQuanti-Blue™ Cell Viability Assay Kit was implemented to proof viability of L929 mouse fibroblasts. The predominant part of the HG eluates generated only a marginal reduction of less than 15% cell viability at 100% eluate concentration. This underlines the excellent suitability of these HGs for biomedical applications and revealed some promising candidates for the development of drug depots for implants.

Location
Deutsche Nationalbibliothek Frankfurt am Main
Extent
Online-Ressource
Language
Englisch

Bibliographic citation
Promising biocompatible hydrogels of crosslinked polyelectrolytes for biomedical applications ; volume:3 ; number:2 ; year:2017 ; pages:695-698 ; extent:4
Current directions in biomedical engineering ; 3, Heft 2 (2017), 695-698 (gesamt 4)

Creator
Brietzke, Andreas
von der Ehe, Christian
Illner, Sabine
Matschegewski, Claudia
Grabow, Niels
Kragl, Udo

DOI
10.1515/cdbme-2017-0147
URN
urn:nbn:de:101:1-2023030713101717212913
Rights
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
Last update
14.08.2025, 10:44 AM CEST

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Associated

  • Brietzke, Andreas
  • von der Ehe, Christian
  • Illner, Sabine
  • Matschegewski, Claudia
  • Grabow, Niels
  • Kragl, Udo

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