Promising biocompatible hydrogels of crosslinked polyelectrolytes for biomedical applications
Abstract: For the development of intelligent implant systems hydrogels (HG) from crosslinked ionic liquids feature a high potential to be utilised as a drug depot. Biocompatibility of the HGs is one key prerequisite for biomedical applications. HGs were polymerised from a variety of different ionic monomers based on methacrylate, methacrylamide, styrene or vinyl imidazolium derivatives in aqueous solution. N,N'-methylenebisacrylamide was used as crosslinker. CellQuanti-Blue™ Cell Viability Assay Kit was implemented to proof viability of L929 mouse fibroblasts. The predominant part of the HG eluates generated only a marginal reduction of less than 15% cell viability at 100% eluate concentration. This underlines the excellent suitability of these HGs for biomedical applications and revealed some promising candidates for the development of drug depots for implants.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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Promising biocompatible hydrogels of crosslinked polyelectrolytes for biomedical applications ; volume:3 ; number:2 ; year:2017 ; pages:695-698 ; extent:4
Current directions in biomedical engineering ; 3, Heft 2 (2017), 695-698 (gesamt 4)
- Urheber
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Brietzke, Andreas
von der Ehe, Christian
Illner, Sabine
Matschegewski, Claudia
Grabow, Niels
Kragl, Udo
- DOI
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10.1515/cdbme-2017-0147
- URN
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urn:nbn:de:101:1-2023030713101717212913
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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14.08.2025, 10:44 MESZ
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Beteiligte
- Brietzke, Andreas
- von der Ehe, Christian
- Illner, Sabine
- Matschegewski, Claudia
- Grabow, Niels
- Kragl, Udo
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