Preparation of Micron and Submicron Particles via Spray Drying and Electrostatic Precipitation
Abstract: Small particles are of great interest in a variety of applications. Spray drying is a common technique for particle synthesis, but it is limited with respect to sizes below 10 μm. Therefore, a new laboratory‐scale spray dryer was designed to address this issue. A novel aerosol generator consisting of a piezo crystal in a swirl chamber was designed to obtain droplets in the low micrometer range. After drying and cooling, particles were deposited in a molten carrier, using melt electrostatic precipitation. The median particle size of three pharmaceutical drug substances was 2 μm. The size distribution was particularly narrow, with span values of about 1.1. Spray drying is a sufficient technique to produce small drug particles below 5 μm with ultrasonic atomization at high frequencies. Electrostatic precipitation in a molten carrier is a suitable method to capture these particles.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Preparation of Micron and Submicron Particles via Spray Drying and Electrostatic Precipitation ; day:21 ; month:12 ; year:2022 ; extent:8
Chemical engineering & technology ; (21.12.2022) (gesamt 8)
- Creator
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Justen, Anna
Kurth, Christopher
Schaldach, Gerhard
Thommes, Markus
- DOI
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10.1002/ceat.202200357
- URN
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urn:nbn:de:101:1-2022122214114145688986
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:28 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Justen, Anna
- Kurth, Christopher
- Schaldach, Gerhard
- Thommes, Markus
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