Diastereoselective Alkylation of Activated Nitrogen Heterocycles with Alkenyl Boronate Complexes

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Abstract: Alkenyl boronate complexes react with acylated quinolines and isoquinolines via 1,2‐metalate rearrangement to give alkylated, dearomatized heterocycles in good yields, diastereoselectivities, and regioselectivities. This multi‐component coupling is highly modular and can be used to access a wide scope of heterocyclic scaffolds. Chiral boronic esters made through this methodology possess high synthetic potential and can be transformed into various functional groups in one step without racemization.

Location: Deutsche Nationalbibliothek Frankfurt am Main

Extent: Online-Ressource

Language: Englisch

Bibliographic citation: Diastereoselective Alkylation of Activated Nitrogen Heterocycles with Alkenyl Boronate Complexes ; day:06 ; month:03 ; year:2023 ; extent:9
Angewandte Chemie / International edition. International edition ; (06.03.2023) (gesamt 9)

Creator: McGettigan, James E.
Ready, Joseph M.

DOI: 10.1002/anie.202216961

URN: urn:nbn:de:101:1-2023030714140020061270

Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.

Last update: 14.08.2025, 11:01 AM CEST

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McGettigan, James E.
Ready, Joseph M.

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Diastereoselective Alkylation of Activated Nitrogen Heterocycles with Alkenyl Boronate Complexes

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Other Objects (12)

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