Softness‐Aided Mild Hyperthermia Boosts Stiff Nanomedicine by Regulating Tumor Mechanics
Abstract: Aberrant tumor mechanical microenvironment (TMME), featured with overactivated cancer‐associated fibroblasts (CAFs) and excessive extracellular matrix (ECM), severely restricts penetration and accumulation of cancer nanomedicines, while mild‐hyperthermia photothermal therapy (mild‐PTT) has been developed to modulate TMME. However, photothermal agents also encounter the barriers established by TMME, manifesting in limited penetration and heterogeneous distribution across tumor tissues and ending with attenuated efficiency in TMME regulation. Herein, it is leveraged indocyanine green (ICG)‐loaded soft nanogels with outstanding deformability, for efficient tumor penetration and uniform distribution, in combination with mild‐PTT to achieve potent TMME regulation by inhibiting CAFs and degrading ECM. As a result, doxorubicin (DOX)‐loaded stiff nanogels gain greater benefits in tumor penetration and antitumor efficacy than soft counterparts from softness‐mediated mild‐PTT. This study reveals the crucial role of nanomedicine mechanical properties in tumor distribution and provides a novel strategy for overcoming the barriers of solid tumors with soft deformable nanogels.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Softness‐Aided Mild Hyperthermia Boosts Stiff Nanomedicine by Regulating Tumor Mechanics ; day:05 ; month:05 ; year:2024 ; extent:14
Advanced science ; (05.05.2024) (gesamt 14)
- Creator
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Li, Zheng
Zhu, Yabo
Zhang, Zhijie
Wang, Huimin
Wang, Chong
Xu, Chen
Li, Shiyou
Zhang, Shuya
Yang, Xiangliang
Li, Zifu
- DOI
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10.1002/advs.202306730
- URN
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urn:nbn:de:101:1-2405051404288.614714686874
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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14.08.2025, 10:45 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Li, Zheng
- Zhu, Yabo
- Zhang, Zhijie
- Wang, Huimin
- Wang, Chong
- Xu, Chen
- Li, Shiyou
- Zhang, Shuya
- Yang, Xiangliang
- Li, Zifu
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