Palladium‐Catalyzed Carbonylative Multicomponent Fluoroalkylation of 1,3‐Enynes: Concise Construction of Diverse Cyclic Compounds

Abstract: Multicomponent reactions, particularly those entailing four or more reagents, have presented a longstanding challenge due to the inherent complexities associated with balancing reactivity, selectivity, and compatibility. In this study, we describe a palladium‐catalyzed multi‐component fluoroalkylative carbonylation of 1,3‐enynes. A series of products featuring three active functional groups‐allene, fluoroalkyl, and carboxyl, were efficiently and selectively integrated in a single chemical operation. Furthermore, more intricate fluoroalkyl‐substituted pyrimidinones can be constructed by simply altering the 1,3‐bisnucleophilic reagent. This approach also provides a valuable strategy for the late‐stage modification of naturally occurring molecules and concise construction of diverse cyclic compounds.

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: Palladium‐Catalyzed Carbonylative Multicomponent Fluoroalkylation of 1,3‐Enynes: Concise Construction of Diverse Cyclic Compounds ; day:11 ; month:01 ; year:2024 ; extent:9 ; Angewandte Chemie ; (11.01.2024) (gesamt 9)

Contributors, Places and Time

• Creator: Kuai, Chang‐Sheng ; Teng, Bing‐Hong ; Wu, Xiao-Feng

Further information

• DOI: 10.1002/ange.202318257
• URN: urn:nbn:de:101:1-2024011214054304988365
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 15.08.2025, 7:29 AM CEST