Palladium‐Catalyzed Carbonylative Multicomponent Fluoroalkylation of 1,3‐Enynes: Concise Construction of Diverse Cyclic Compounds

Abstract: Multicomponent reactions, particularly those entailing four or more reagents, have presented a longstanding challenge due to the inherent complexities associated with balancing reactivity, selectivity, and compatibility. In this study, we describe a palladium‐catalyzed multi‐component fluoroalkylative carbonylation of 1,3‐enynes. A series of products featuring three active functional groups‐allene, fluoroalkyl, and carboxyl, were efficiently and selectively integrated in a single chemical operation. Furthermore, more intricate fluoroalkyl‐substituted pyrimidinones can be constructed by simply altering the 1,3‐bisnucleophilic reagent. This approach also provides a valuable strategy for the late‐stage modification of naturally occurring molecules and concise construction of diverse cyclic compounds.

Angaben zum Objekt

• Standort: Deutsche Nationalbibliothek Frankfurt am Main
• Umfang: Online-Ressource
• Sprache: Englisch

Verweise und Beziehungen

• Erschienen in: Palladium‐Catalyzed Carbonylative Multicomponent Fluoroalkylation of 1,3‐Enynes: Concise Construction of Diverse Cyclic Compounds ; day:11 ; month:01 ; year:2024 ; extent:9 ; Angewandte Chemie ; (11.01.2024) (gesamt 9)

Beteiligte, Orts- und Zeitangaben

• Urheber: Kuai, Chang‐Sheng ; Teng, Bing‐Hong ; Wu, Xiao-Feng

Weitere Informationen

• DOI: 10.1002/ange.202318257
• URN: urn:nbn:de:101:1-2024011214054304988365
• Rechteinformation: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Letzte Aktualisierung: 15.08.2025, 07:29 MESZ