VHL and Hypoxia regulated genes in sympatho-adrenal cell lineage development and disease

Hochschulschrift

Zusammenfassung: VHL and Hypoxia regulated genes in sympatho- adrenal cell lineage Development and DiseaseAbstractCells of the sympatho-adrenal (SA) cell lineage develop from neural crest cells (NCCs). Abnormal development of SA cells has been linked to various tumors, including neuroblastoma (NB), and Pheochromocytoma (PCC). In humans mutations of the Von Hippel Lindau tumor suppressor gene (VHL), a negative regulator of hypoxia inducible factors, is one of the major causes of PCC development. .Mammalian embryos develop within a hypoxic environment, under the influence of hypoxia inducible factors (HIFs). HIFs have been linked to various diseases, including NB, due to their impact on cellular differentiation. Delta like homolog 1 (DLK-1) is another gene implicated in neuroblastoma, which is hypoxia regulated and lies downstream of HIF system. However, the main role of VHL and hypoxia-inducible factors during normal development of SA cells is unclear up to date.The aim of the current study was to investigate the in vivo role of VHL on the normal development of SA cells and to investigate, whether the loss of VHL function leads to SA derived tumor development as pheochromocytoma.

Angaben zum Objekt

• Standort: Deutsche Nationalbibliothek Frankfurt am Main
• Umfang: Online-Ressource
• Sprache: Englisch
• Anmerkungen: Albert-Ludwigs-Universität Freiburg, Dissertation, 2016

Klassifikation und Themen

• Schlagwort: Krebs ; Onkologie

Beteiligte, Orts- und Zeitangaben

• Ereignis: Veröffentlichung
• (wo): Freiburg
• (wer): Universität
• (wann): 2016
• Urheber: Ali Omer Elfaitwri, Tehani
• Beteiligte Personen und Organisationen: Krieglstein, Kerstin

Weitere Informationen

• DOI: 10.6094/UNIFR/11085
• URN: urn:nbn:de:bsz:25-freidok-110851
• Rechteinformation: Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Letzte Aktualisierung: 25.03.2025, 13:56 MEZ