Hochschulschrift
VHL and Hypoxia regulated genes in sympatho-adrenal cell lineage development and disease
Zusammenfassung: VHL and Hypoxia regulated genes in sympatho- adrenal cell lineage Development and DiseaseAbstractCells of the sympatho-adrenal (SA) cell lineage develop from neural crest cells (NCCs). Abnormal development of SA cells has been linked to various tumors, including neuroblastoma (NB), and Pheochromocytoma (PCC). In humans mutations of the Von Hippel Lindau tumor suppressor gene (VHL), a negative regulator of hypoxia inducible factors, is one of the major causes of PCC development. .Mammalian embryos develop within a hypoxic environment, under the influence of hypoxia inducible factors (HIFs). HIFs have been linked to various diseases, including NB, due to their impact on cellular differentiation. Delta like homolog 1 (DLK-1) is another gene implicated in neuroblastoma, which is hypoxia regulated and lies downstream of HIF system. However, the main role of VHL and hypoxia-inducible factors during normal development of SA cells is unclear up to date.The aim of the current study was to investigate the in vivo role of VHL on the normal development of SA cells and to investigate, whether the loss of VHL function leads to SA derived tumor development as pheochromocytoma.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Notes
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Albert-Ludwigs-Universität Freiburg, Dissertation, 2016
- Keyword
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Krebs
Onkologie
- Event
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Veröffentlichung
- (where)
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Freiburg
- (who)
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Universität
- (when)
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2016
- Creator
- Contributor
- DOI
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10.6094/UNIFR/11085
- URN
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urn:nbn:de:bsz:25-freidok-110851
- Rights
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Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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14.08.2025, 11:02 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Object type
- Hochschulschrift
Associated
- Ali Omer Elfaitwri, Tehani
- Krieglstein, Kerstin
- Universität
Time of origin
- 2016
Other Objects (12)
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NADH elevation during chronic hypoxia leads to VHL-mediated HIF-1α degradation via SIRT1 inhibition
Identification of 3 novel VHL germ-line mutations in Danish VHL patients
Von Hippel–Lindau (VHL) disease and VHL-associated tumors in Indian subjects: VHL gene testing in a resource constraint setting
CpG methylation profiling in VHL related and VHL unrelated renal cell carcinoma
Von Hippel-Lindau-Syndrom (VHL)
Seladin-1 expression is regulated by promoter methylation in adrenal cancer
Early hypoxia-regulated genes in rice and Arabidopsis thaliana
Mutationsanalyse des VHL-Tumorsuppressorgens vor dem Hintergrund der erblichen VHL-Erkrankung und Karzinogenexposition beim sporadischen Nierenzellkarzinom
Hypoxia differentially regulated CXCR4 and CXCR7 signaling in colon cancer
VHL inactivation without hypoxia is sufficient to achieve genome hypermethylation
Regulated necrosis in the adrenal glands and the kidney
ER-stress promotes VHL-independent degradation of hypoxia-inducible factors via FBXW1A/βTrCP
NADH elevation during chronic hypoxia leads to VHL-mediated HIF-1α degradation via SIRT1 inhibition
Identification of 3 novel VHL germ-line mutations in Danish VHL patients
Von Hippel–Lindau (VHL) disease and VHL-associated tumors in Indian subjects: VHL gene testing in a resource constraint setting
CpG methylation profiling in VHL related and VHL unrelated renal cell carcinoma
Von Hippel-Lindau-Syndrom (VHL)
Seladin-1 expression is regulated by promoter methylation in adrenal cancer
Early hypoxia-regulated genes in rice and Arabidopsis thaliana
Mutationsanalyse des VHL-Tumorsuppressorgens vor dem Hintergrund der erblichen VHL-Erkrankung und Karzinogenexposition beim sporadischen Nierenzellkarzinom
Hypoxia differentially regulated CXCR4 and CXCR7 signaling in colon cancer
VHL inactivation without hypoxia is sufficient to achieve genome hypermethylation
Regulated necrosis in the adrenal glands and the kidney
ER-stress promotes VHL-independent degradation of hypoxia-inducible factors via FBXW1A/βTrCP
NADH elevation during chronic hypoxia leads to VHL-mediated HIF-1α degradation via SIRT1 inhibition
Identification of 3 novel VHL germ-line mutations in Danish VHL patients
Von Hippel–Lindau (VHL) disease and VHL-associated tumors in Indian subjects: VHL gene testing in a resource constraint setting
CpG methylation profiling in VHL related and VHL unrelated renal cell carcinoma
Von Hippel-Lindau-Syndrom (VHL)
Seladin-1 expression is regulated by promoter methylation in adrenal cancer
Early hypoxia-regulated genes in rice and Arabidopsis thaliana
Mutationsanalyse des VHL-Tumorsuppressorgens vor dem Hintergrund der erblichen VHL-Erkrankung und Karzinogenexposition beim sporadischen Nierenzellkarzinom