The many faces of ribosome translocation along the mRNA: reading frame maintenance, ribosome frameshifting and translational bypassing
Abstract: In each round of translation elongation, the ribosome translocates along the mRNA by precisely one codon. Translocation is promoted by elongation factor G (EF-G) in bacteria (eEF2 in eukaryotes) and entails a number of precisely-timed large-scale structural rearrangements. As a rule, the movements of the ribosome, tRNAs, mRNA and EF-G are orchestrated to maintain the exact codon-wise step size. However, signals in the mRNA, as well as environmental cues, can change the timing and dynamics of the key rearrangements leading to recoding of the mRNA into production of trans-frame peptides from the same mRNA. In this review, we discuss recent advances on the mechanics of translocation and reading frame maintenance. Furthermore, we describe the mechanisms and biological relevance of non-canonical translocation pathways, such as hungry and programmed frameshifting and translational bypassing, and their link to disease and infection.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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The many faces of ribosome translocation along the mRNA: reading frame maintenance, ribosome frameshifting and translational bypassing ; volume:404 ; number:8-9 ; year:2023 ; pages:755-767 ; extent:013
Biological chemistry ; 404, Heft 8-9 (2023), 755-767 (gesamt 013)
- Creator
- DOI
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10.1515/hsz-2023-0142
- URN
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urn:nbn:de:101:1-2023090714165840453373
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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14.08.2025, 10:46 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Poulis, Panagiotis
- Peske, Frank
- Rodnina, Marina
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Ribosome dynamics during spontaneous frameshifting
Kinetics of subunit rotation of the ribosome during tRNA-mRNA translocation
Recoding of viral mRNAs by –1 programmed ribosome frameshifting
Altered tRNA dynamics during translocation on slippery mRNA as determinant of spontaneous ribosome frameshifting
Coupling of GTP hydrolysis by EF-G to tRNA and mRNA translocation through the ribosome
Molecular mechanisms of substrate selection and protein folding on the ribosome
Ribosome selectivity and nascent chain context in modulating the incorporation of fluorescent non-canonical amino acid into proteins
Release of a Natural mRNA During Recycling of the Prokaryotic Ribosome
Recognition Elements for Elongation Factor P on the Ribosome
Co‐translational insertion and topogenesis of bacterial membrane proteins monitored in real time
Ribosome Processivity and Co-translational Protein Folding
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Ribosome dynamics during spontaneous frameshifting
Kinetics of subunit rotation of the ribosome during tRNA-mRNA translocation
Recoding of viral mRNAs by –1 programmed ribosome frameshifting
Altered tRNA dynamics during translocation on slippery mRNA as determinant of spontaneous ribosome frameshifting
Coupling of GTP hydrolysis by EF-G to tRNA and mRNA translocation through the ribosome
Molecular mechanisms of substrate selection and protein folding on the ribosome
Ribosome selectivity and nascent chain context in modulating the incorporation of fluorescent non-canonical amino acid into proteins
Release of a Natural mRNA During Recycling of the Prokaryotic Ribosome
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