The many faces of ribosome translocation along the mRNA: reading frame maintenance, ribosome frameshifting and translational bypassing
Abstract: In each round of translation elongation, the ribosome translocates along the mRNA by precisely one codon. Translocation is promoted by elongation factor G (EF-G) in bacteria (eEF2 in eukaryotes) and entails a number of precisely-timed large-scale structural rearrangements. As a rule, the movements of the ribosome, tRNAs, mRNA and EF-G are orchestrated to maintain the exact codon-wise step size. However, signals in the mRNA, as well as environmental cues, can change the timing and dynamics of the key rearrangements leading to recoding of the mRNA into production of trans-frame peptides from the same mRNA. In this review, we discuss recent advances on the mechanics of translocation and reading frame maintenance. Furthermore, we describe the mechanisms and biological relevance of non-canonical translocation pathways, such as hungry and programmed frameshifting and translational bypassing, and their link to disease and infection.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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The many faces of ribosome translocation along the mRNA: reading frame maintenance, ribosome frameshifting and translational bypassing ; volume:404 ; number:8-9 ; year:2023 ; pages:755-767 ; extent:013
Biological chemistry ; 404, Heft 8-9 (2023), 755-767 (gesamt 013)
- Urheber
- DOI
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10.1515/hsz-2023-0142
- URN
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urn:nbn:de:101:1-2023090714165840453373
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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14.08.2025, 10:46 MESZ
Datenpartner
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Poulis, Panagiotis
- Peske, Frank
- Rodnina, Marina
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