Lipopolysaccharide-induced neuroinflammation as a bridge to understand neurodegeneration
Abstract: A large body of experimental evidence suggests that neuroinflammation is a key pathological event triggering and perpetuating the neurodegenerative process associated with many neurological diseases. Therefore, different stimuli, such as lipopolysaccharide (LPS), are used to model neuroinflammation associated with neurodegeneration. By acting at its receptors, LPS activates various intracellular molecules, which alter the expression of a plethora of inflammatory mediators. These factors, in turn, initiate or contribute to the development of neurodegenerative processes. Therefore, LPS is an important tool for the study of neuroinflammation associated with neurodegenerative diseases. However, the serotype, route of administration, and number of injections of this toxin induce varied pathological responses. Thus, here, we review the use of LPS in various models of neurodegeneration as well as discuss the neuroinflammatory mechanisms induced by this toxin that could underpin the pathological events linked to the neurodegenerative process
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Anmerkungen
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issn: 1422-0067
- Schlagwort
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Lipopolysaccharide
Entzündung
Nervendegeneration
Alzheimerkrankheit
Parkinson-Krankheit
Myatrophische Lateralsklerose
Huntington-Chorea
- Ereignis
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Veröffentlichung
- (wo)
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Freiburg
- (wer)
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Universität
- (wann)
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2019
- Urheber
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Ribeiro Alvares Batista, Carla
Gomes, Giovanni Freitas
Candelario-Jalil, Eduardo
Fiebich, Bernd L.
Oliveira, Antônio Carlos Pinheiro de
- DOI
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10.3390/ijms20092293
- URN
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urn:nbn:de:bsz:25-freidok-1500517
- Rechteinformation
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Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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25.03.2025, 13:45 MEZ
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Beteiligte
- Ribeiro Alvares Batista, Carla
- Gomes, Giovanni Freitas
- Candelario-Jalil, Eduardo
- Fiebich, Bernd L.
- Oliveira, Antônio Carlos Pinheiro de
- Universität
Entstanden
- 2019
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TAB: Ergebnisse z. d. Lipopolysaccharide