Turmeric extract (Curcuma longa) mediates anti-oxidative effects by reduction of nitric oxide, iNOS Protein-, and mRNA-synthesis in BV2 microglial cells
Abstract: Plant-derived products have been used since the beginnings of human history to treat various pathological conditions. Practical experience as well as a growing body of research suggests the benefits of the use of turmeric (Curcuma longa) and some of its active components in the reduction of oxidative stress, a mechanism leading to neurodegeneration. In this current study, we investigated the effects of a preparation of Curcuma longa, and its constituents curcumin, tetrahydrocurcumin, and curcumenol, in one of the molecular pathways leading to oxidative stress, which is the release of NO, a free radical involved in stress conditions, using the BV2 microglial cell line. The concentration-dependent reduction of NO is linked to reduced amounts of iNOS protein- and mRNA-synthesis and is possibly mediated by the phosphorylation of mitogen-activated protein kinases (MAPK) such as p42/44 or p38 MAPK. Therefore, the use of turmeric extract is a promising therapeutic option for diseases linked to the dysregulation of oxidative stress, with fewer side-effects in comparison to the currently used pharmacotherapeutics
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Anmerkungen
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Molecules. - 27, 3 (2022) , 784, ISSN: 1420-3049
- Ereignis
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Veröffentlichung
- (wo)
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Freiburg
- (wer)
-
Universität
- (wann)
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2022
- Urheber
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Streyczek, Jana
Apweiler, Matthias
Sun, Lu
Fiebich, Bernd L.
- DOI
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10.3390/molecules27030784
- URN
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urn:nbn:de:bsz:25-freidok-2241594
- Rechteinformation
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Kein Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
-
15.08.2025, 07:24 MESZ
Datenpartner
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Beteiligte
- Streyczek, Jana
- Apweiler, Matthias
- Sun, Lu
- Fiebich, Bernd L.
- Universität
Entstanden
- 2022
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