Hydrogel Microparticle‐Templated Anti‐Solvent Crystallization of Small‐Molecule Drugs

Abstract: Conventional formulation strategies for hydrophobic small‐molecule drug products frequently include mechanical milling to decrease active pharmaceutical ingredient (API) crystal size and subsequent granulation processes to produce an easily handled powder. A hydrogel‐templated anti‐solvent crystallization method is presented for the facile fabrication of microparticles containing dispersed nanocrystals of poorly soluble API. Direct crystallization within a porous hydrogel particle template yields core–shell structures in which the hydrogel core containing API nanocrystals is encased by a crystalline API shell. The process of controllable loading (up to 64% w/w) is demonstrated, and tailored dissolution profiles are achieved by simply altering the template particle size. API release is well described by a shrinking core model. Overall, the approach is a simple, scalable and potentially generalizable method that enables novel means of independently controlling both API crystallization and excipient characteristics, offering a “designer” drug particle system.

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: Hydrogel Microparticle‐Templated Anti‐Solvent Crystallization of Small‐Molecule Drugs ; day:07 ; month:01 ; year:2022 ; extent:8 ; Advanced healthcare materials ; (07.01.2022) (gesamt 8)

Contributors, Places and Time

• Creator: Bora, Meghali ; Hsu, Myat Noe ; Khan, Saif A. ; Doyle, Patrick S.

Further information

• DOI: 10.1002/adhm.202102252
• URN: urn:nbn:de:101:1-2022010714102312360383
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 15.08.2025, 7:28 AM CEST