Hydrogel Microparticle‐Templated Anti‐Solvent Crystallization of Small‐Molecule Drugs
Abstract: Conventional formulation strategies for hydrophobic small‐molecule drug products frequently include mechanical milling to decrease active pharmaceutical ingredient (API) crystal size and subsequent granulation processes to produce an easily handled powder. A hydrogel‐templated anti‐solvent crystallization method is presented for the facile fabrication of microparticles containing dispersed nanocrystals of poorly soluble API. Direct crystallization within a porous hydrogel particle template yields core–shell structures in which the hydrogel core containing API nanocrystals is encased by a crystalline API shell. The process of controllable loading (up to 64% w/w) is demonstrated, and tailored dissolution profiles are achieved by simply altering the template particle size. API release is well described by a shrinking core model. Overall, the approach is a simple, scalable and potentially generalizable method that enables novel means of independently controlling both API crystallization and excipient characteristics, offering a “designer” drug particle system.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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Hydrogel Microparticle‐Templated Anti‐Solvent Crystallization of Small‐Molecule Drugs ; day:07 ; month:01 ; year:2022 ; extent:8
Advanced healthcare materials ; (07.01.2022) (gesamt 8)
- Urheber
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Bora, Meghali
Hsu, Myat Noe
Khan, Saif A.
Doyle, Patrick S.
- DOI
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10.1002/adhm.202102252
- URN
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urn:nbn:de:101:1-2022010714102312360383
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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15.08.2025, 07:28 MESZ
Datenpartner
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Bora, Meghali
- Hsu, Myat Noe
- Khan, Saif A.
- Doyle, Patrick S.
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